文献类型：期刊文献

英文题名：Molecular interactions between terpenoid mosquito repellents and human-secreted attractants

作者：Liao, Shengliang[1] Song, Jie[2] Wang, Zongde[1] Chen, Jinzhu[1] Fan, Guorong[1] Song, Zhanqian[3] Shang, Shibin[3] Chen, Shangxing[1] Wang, Peng[1]

第一作者：Liao, Shengliang

通信作者：Song, J[1]

机构：[1]Jiangxi Agr Univ, Coll Forestry, Nanchang 330045, Jiangxi, Peoples R China;[2]Univ Michigan, Dept Chem & Biochem, Flint, MI 48502 USA;[3]Chinese Acad Forestry, Inst Chem Ind Forest Prod, Nanjing 210042, Jiangsu, Peoples R China

年份：2014

卷号：24

期号：3

起止页码：773-779

外文期刊名：BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

收录：;Scopus(收录号：2-s2.0-84893675109);WOS:【SCI-EXPANDED(收录号:WOS:000330120800012)】；

基金：This work has been supported by the Special Fund of National Forestry Public Welfare Scientific Research Project of China (201304602), the Major Disciplines Academic and Technical Leader Training Program of Jiangxi Province (20133BCB22004), Science and Technology Support Program of Jiangxi Province (20132BBF60057), the International S&T Cooperation Program of China (2011DFA32440), and RCAC Award from the University of Michigan-Flint.

语种：英文

外文关键词：Terpenoid; Mosquito repellent; Human-secreted attractant; Molecular interaction; Repellency

摘要：Molecular interactions between terpenoid mosquito repellents and three typical human-secreted attractants, ammonia, 1-octen-3-ol, and formic acid were studied. Relative energies, bond distances, and bond angles of the molecular interactions were obtained at HF level to evaluate the interaction intensity and types. The effects of molecular interactions on repellency were investigated by the subsequent quantitative structure-activity relationship (QSAR) study. The results of this study suggest that attractant-repellent interaction should not be ignored and could be helpful for future research on the repelling mechanism of mosquito repellents. (C) 2014 Elsevier Ltd. All rights reserved.