文献类型：期刊文献

英文题名：Cooperative action of polymer architecture and size on the mechanical and water retention properties of the Gleditsia sinensis galactomannan-based hydrogel

作者：Yuyu, E.[1] Chang, Zeyu[1] Li, Wen[2] Li, Pengfei[2] Lei, Fuhou[2] Jiang, Jianxin[1] Duan, Wengui[3] Ju, Yunshan[4] Peng, Xiaopeng[5] Wang, Kun[1]

第一作者：Yuyu, E.

通信作者：Wang, K[1]

机构：[1]Beijing Forestry Univ, MOE Engn Res Ctr Forestry Biomass Mat & Bioenergy, Dept Chem & Chem Engn, Beijing 100083, Peoples R China;[2]Guangxi Minzu Univ, Key Lab Chem & Engn Forest Prod,State Ethn Affairs, Guangxi Key Lab Chem & Engn Forest Prod, Guangxi Collaborat Innovat Ctr Chem & Engn Forest, Nanning 530006, Peoples R China;[3]Guangxi Univ, Sch Chem & Chem Engn, Nanning 530004, Peoples R China;[4]Lanzhou Biotech Dev Co Ltd, Lanzhou 730046, Peoples R China;[5]Chinese Acad Forestry, State Key Lab Tree Genet & Breeding, Key Lab Tree Breeding & Cultivat, Natl Forestry & Grassland Adm,Res Inst Forestry, Beijing 100091, Peoples R China

年份：2024

卷号：220

外文期刊名：INDUSTRIAL CROPS AND PRODUCTS

收录：;EI(收录号：20243416911614);Scopus(收录号：2-s2.0-85201520164);WOS:【SCI-EXPANDED(收录号:WOS:001297992600001)】；

基金：This work was financially supported by the National Key Research and Development Program of China (2022YFD2200804) , and the Guangxi Key Laboratory of Chemistry Engineering of Forest Products (GXFK2306) .

语种：英文

外文关键词：Galactomannan; Hyaluronic acid; Chemical cross-linking; Water retention; Hydrogel

摘要：A novel hyaluronic acid/ Gleditsia sinensis galactomannan hydrogel was prepared using various alkyl glycidyl ethers as cross-linking agents. The morphological, physicochemical, and mechanical properties of the obtained hydrogels were comparatively investigated and discussed. The optimal hydrogel exhibited high storage modulus (210 P), loss modulus (27.8 P), and water retention properties (95 %). The diffusion rate constant of water molecules in freeze-dried hydrogels exhibited a positive correlation with water uptake/equilibrium swelling rate, and the water molecules exhibited a non-Fickian type diffusion mechanism. Hydrogels with high molecular weight (Mw) hyaluronic acid showed higher water retention properties than those with low-Mw hyaluronic acid (80 % water retention properties). The molecular docking simulations of hyaluronic acid confirmed the higher formation energies of the high-Mw hyaluronic acid (-14.98 Kcal/mol) than that of the low-Mw hyaluronic acid (-6.90 Kcal/mol). This study offers a new design strategy for a water retention hydrogel by optimizing the cross- linked dimension with various-length polymer chains as cross-linkers. These remarkable advantages make hydrogels have enormous potential in the application of cosmetics and biomedical.