文献类型：期刊文献

英文题名：High-performance nanomesh-structured cellulose as a versatile pharmaceutical excipient

作者：Li, Xiaowen[1] Ye, Dongdong[3] Xiang, Zhongrun[2] Wang, Huai[1] Wang, Huiqing[2] Lu, Yun[4] Yao, Risheng[1]

第一作者：Li, Xiaowen

通信作者：Yao, RS[1];Wang, HQ[2];Lu, Y[3]

机构：[1]Hefei Univ Technol, Sch Food & Biol Engn, Hefei 230009, Anhui, Peoples R China;[2]Hefei Univ Technol, Sch Chem & Chem Engn, Hefei 230009, Anhui, Peoples R China;[3]Wuyi Univ, Sch Text Mat & Engn, Jiangmen 529020, Peoples R China;[4]Chinese Acad Forestry, Res Inst Wood Ind, Xiangshan Rd, Beijing 100091, Peoples R China

年份：2023

卷号：197

外文期刊名：INDUSTRIAL CROPS AND PRODUCTS

收录：;EI(收录号：20231213780327);Scopus(收录号：2-s2.0-85150438089);WOS:【SCI-EXPANDED(收录号:WOS:000955348100001)】；

基金：Acknowledgements The authors are grateful for the financial support of Major Scientificand Technological Special Project of Anhui Province (202003a05020060) , Key Research and development program of Anhui Province (2022a05020059, 202004a06020041) and the National Nat-ural Science Foundation of China (52103124, 32122058, 31870535) .

语种：英文

外文关键词：Cellulose nanomesh; Hydrolysis method; Micro-nano structure; Drug delivery; Abuse-deterrent

摘要：Biocompatible cellulose has been used as a pharmaceutical excipient for several decades. However, there are still shortcomings, such as low drug loading, slow disintegration, and easy drug extraction. Herein, we describe a novel process for manufacturing cellulose nanomesh (CNM), a new structured nanocellulose with a high surface area of 98.37 m(2)g(-1) and a high yield above 88%. This process combines mild acid vapor with a dilute enzymatic hydrolysis preparation method. The unique nanomesh structure clearly demonstrates benefits as superior drug carriers, including a high drug loading rate (>81.2%), miniaturizing volume, ultrafast disintegration time (<7 s), long-term sustained release (22 h), and also a strong drug-abuse deterrent effect. Our work suggests that the CNM produces great potential as a promising multi-functional drug carrier to realize tablet miniaturization, drug abuse-deterrent, and drug slow and controlled release.