文献类型：期刊文献

英文题名：PRMD: an integrated database for plant RNA modifications

作者：Lang, Xiaoqiang[2,3] Yu, Chunyan[4] Shen, Mengyuan[1] Gu, Lei[5,6] Qian, Qian[1] Zhou, Degui[1] Tan, Jiantao[1] Li, Yiliang[7] Peng, Xin[1] Diao, Shu[8] Deng, Zhujun[9] Ruan, Zhaohui[10] Xu, Zhi[11] Xing, Junlian[1] Li, Chen[1] Wang, Runfeng[12] Ding, Changjun[2] Cao, Yi[3] Liu, Qi[1]

第一作者：Lang, Xiaoqiang

通信作者：Liu, Q[1];Ding, CJ[2];Cao, Y[3]

机构：[1]Guangdong Acad Agr Sci, Key Lab Genet & Breeding High Qual Rice Southern C, Guangdong Key Lab New Technol Rice Breeding, Rice Res Inst,Minist Agr & Rural Affairs,Guangdong, 510640, Guangzhou, Chin, Myanmar;[2]Chinese Acad Forestry, Res Inst Forestry, State Key Lab Tree Genet & Breeding, Key Lab Tree Breeding & Cultivat,State Forestry Ad, Beijing 100091, Peoples R China;[3]Sichuan Univ, Coll Life Sci, Microbiol & Metab Engn Key Lab Sichuan Prov, Chengdu 610041, Sichuan, Peoples R China;[4]Sichuan Univ, West China Hosp, Frontiers Sci Ctr Dis Related Mol Network, Lab Omics Technol & Bioinformat, Chengdu 610041, Sichuan, Peoples R China;[5]Max Planck Inst Heart & Lung Res, Epigenet Lab, Parkstr 1, D-61231 Bad Nauheim, Germany;[6]Cardiopulm Inst CPI, Parkstr 1, D-61231 Bad Nauheim, Germany;[7]Guangdong Acad Forestry, Guangdong Prov Key Lab Silviculture Protect & Util, Guangzhou 510520, Guangdong, Peoples R China;[8]Chinese Acad Forestry, Res Inst Subtrop Forestry, Hangzhou, Peoples R China;[9]Sichuan Univ, West China Hosp, Precis Med Ctr, Precis Med Key Lab Sichuan Prov, Chengdu 610041, Sichuan, Peoples R China;[10]Sun Yat sen Univ, Canc Ctr, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Guangzhou 510060, Peoples R China;[11]Guilin Univ Elect Technol, Guangxi Key Lab Images & Graph Intelligent Proc, Guilin 541004, Peoples R China;[12]Guangdong Acad Agr Sci, Crops Res Inst, Guangdong Prov Key Lab Crop Genet Improvement, Guangzhou, Peoples R China

年份：2023

外文期刊名：NUCLEIC ACIDS RESEARCH

收录：;Scopus(收录号：2-s2.0-85181760965);WOS:【SCI-EXPANDED(收录号:WOS:001081838900001)】；

基金：Author contributions: Conceptualization, L.Q., C.Y. and D.C.; methodology, L.Q., L.X., S.M. and Y.C.; formal analysis, L.X. and Y.C.; investigation, G.L., Q.Q., Z.D., T.J., L.Y., P.X., D.Z., D.S., R.Z. and X.Z.; visualization and database, S.M.; writing-original draft, L.X.; writing-review & editing, L.Q., L.X., D.Z., L.C., X.J., W.R. and S.M.; supervision, D.C., C.Y. and L.Q.

语种：英文

摘要：The scope and function of RNA modifications in model plant systems have been extensively studied, resulting in the identification of an increasing number of novel RNA modifications in recent years. Researchers have gradually revealed that RNA modifications, especially N6-methyladenosine (m6A), which is one of the most abundant and commonly studied RNA modifications in plants, have important roles in physiological and pathological processes. These modifications alter the structure of RNA, which affects its molecular complementarity and binding to specific proteins, thereby resulting in various of physiological effects. The increasing interest in plant RNA modifications has necessitated research into RNA modifications and associated datasets. However, there is a lack of a convenient and integrated database with comprehensive annotations and intuitive visualization of plant RNA modifications. Here, we developed the Plant RNA Modification Database (PRMD; http://bioinformatics.sc.cn/PRMD and http://rnainformatics.org.cn/PRMD) to facilitate RNA modification research. This database contains information regarding 20 plant species and provides an intuitive interface for displaying information. Moreover, PRMD offers multiple tools, including RMlevelDiff, RMplantVar, RNAmodNet and Blast (for functional analyses), and mRNAbrowse, RNAlollipop, JBrowse and Integrative Genomics Viewer (for displaying data). Furthermore, PRMD is freely available, making it useful for the rapid development and promotion of research on plant RNA modifications. Graphical Abstract