文献类型：期刊文献

英文题名：Lignin-based fluorescence hollow nanoparticles: Their preparation, characterization, and encapsulation properties for doxorubicin

作者：Zhou, Yu[1,2,3] Han, Yanming[1] Li, Gaiyun[1] Xiong, Fuquan[1,4] Chu, Fuxiang[1]

第一作者：Zhou, Yu;周宇

通信作者：Han, YM[1];Chu, FX[1]|[a0005728d87cb2daf502d]储富祥;

机构：[1]Chinese Acad Forestry, Res Inst Wood Ind, Xiangshan Rd, Beijing 100089, Peoples R China;[2]Yancheng Inst Technol, Sch Chem & Chem Engn, Jianjun East Rd, Yancheng 224051, Peoples R China;[3]Inst Chem Ind Forest Prod, Jiangsu Prov Biomass Energy & Mat Lab, Longpan Rd, Nanjing 210042, Peoples R China;[4]Cent South Univ Forestry & Technol, Coll Mat Sci & Engn, Shaoshan South Rd, Changsha 410004, Peoples R China

年份：2020

卷号：165

起止页码：2136-2142

外文期刊名：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

收录：;Scopus(收录号：2-s2.0-85094594392);WOS:【SCI-EXPANDED(收录号:WOS:000600773500053)】；

基金：This study was financially support from the National Natural Science Foundation of China (31770610), Jiangsu Province Biomass Energy and Materials Laboratory in the Institute of Chemical Industry of Forest Products, CAF (JSBEM202011), National Natural Science Foundation of China (21801216), and thanks to Tsinghua University for in term of the structure testing of nanoparticles and Shanghai Freedom Biotech CO., Ltd. for the help with the biological cell testing.

语种：英文

外文关键词：Enzymatic hydrolysis lignin; Fluorescence; Hollow nanoparticles; Drug delivery

摘要：Lignin shows strong adsorption, biodegradability and non-toxicity, and has opened a research hotspot in the design and manufacture of controllable nanomaterials for drug delivery. However, lignin-based materials, with both diagnostic and therapeutic functions, have yet to be developed. In this work, enzymatically hydrolysable lignin (EHL) was used to prepare blue fluorescent lignin copolymer by grafting 1-Pyrenebutyric acid onto lignin via amidation reaction and then formed self-assembled nanoparticles. The results show that such lignin-based hollow nanoparticles exhibit characteristics of fluorescent functions, size controlled and stable structure within 15 days. For anticancer drug Doxorubicin, the encapsulation efficiency and drug loading reached, respectively, 50% and 10%. This encapsulation had no cytotoxicity, and sustained-release effect on the drug. The aim of this study was to develop the multifunctional bio-nanomaterials for medical applications, through simple, environmentally friendly, low-cost methods. (C) 2020 Elsevier B.V. All rights reserved.