文献类型：期刊文献

中文题名：异海松酸基酰腙化合物的合成及抗癌活性

英文题名：Synthesis and Anticancer Activity of Acylhydrazone Compounds from Isopimaric Acid

作者：刘娟娟[1,2,3,4] 赵振东[1,2,3,4,5] 卢言菊[1,2,3,4,5] 徐士超[1,2,3,4,5] 陈玉湘[1,2,3,4,5]

第一作者：刘娟娟

通信作者：Zhao, Zhen-Dong

机构：[1]中国林业科学研究院林产化学工业研究所;[2]生物质化学利用国家工程实验室;[3]国家林业局林产化学工程重点开放性实验室;[4]江苏省生物质能源与材料重点实验室;[5]中国林业科学研究院林业新技术研究所

年份：2016

卷号：33

期号：10

起止页码：1195-1200

中文期刊名：精细化工

外文期刊名：Fine Chemicals

收录：CSTPCD;;EI(收录号：20164302941198);Scopus;北大核心:【北大核心2014】；CSCD:【CSCD2015_2016】；

基金：国家自然科学基金资助项目(31370575)~~

语种：中文

中文关键词：异海松酸;酰肼;酰腙;抗癌活性;精细化工中间体

外文关键词：isopimaric acid; acylhydrazine; acylhydrazone; anticancer activity; fine chemical intermediates

分类号：TQ351

摘要：以异海松酸(IPA)为原料,通过羧基酰氯化、肼解和缩合3步反应,合成了5种异海松酸基酰腙化合物(Ⅲa~Ⅲe)。目标化合物的结构通过IR、~1HNMR、^(13)CNMR和MS分析得到确证,并通过MTT法测试目标产物对小鼠HepG2癌细胞的抑制活性。结果表明,5种化合物对小鼠HepG2癌细胞均表现出抑制活性,其中,化合物Ⅲa和Ⅲc在浓度为100μmol/L时对小鼠HepG2癌细胞表现出显著的抑制活性,抑制率分别为75.42%和70.50%。
Five novel acylhydrazone compounds（Ⅲ a ~ Ⅲ e） were synthesized from isopimaric acid（IPA） by the reaction of acyl chlorination,hydrazinolysis and condensation. The structures of the synthesized compounds were confirmed by IR,~1HNMR,^（13）CNMR and MS. The compounds Ⅲ a - Ⅲ e were evaluated for their inhibitory activities against mice HepG2 cell lines by MTT assay. The results indicated that five compounds all exhibited inhibitory activities against HepG2 cancer cell lines.Particularly,compounds Ⅲa and Ⅲc exhibited notable inhibitory effect on HepG2 cancer cell lines at the concentration of 100 μmol/L,and their inhibition ratio reached 75. 42% and 70. 50%,respectively.