文献类型：期刊文献

英文题名：Self-assembled PEG-carboxymethylcellulose nanoparticles/alpha-cyclodextrin hydrogels for injectable and thermosensitive drug delivery

作者：Dai, Lin[1] Liu, Rui[1] Hu, Li-Qiu[1] Wang, Jun-Hui[2] Si, Chuan-Ling[1,2,3,4]

第一作者：Dai, Lin

通信作者：Dai, L[1]

机构：[1]Tianjin Univ Sci & Technol, Tianjin Key Lab Pulp & Paper, Tianjin 300457, Peoples R China;[2]Chinese Acad Forestry, Res Inst Forestry, State Key Lab Tree Genet & Breeding, Beijing 100091, Peoples R China;[3]CAF, Inst Chem Ind Forest Prod, Jiangsu Prov Biomass Energy & Mat Lab, Nanjing 210042, Jiangsu, Peoples R China;[4]South China Univ Technol, State Key Lab Pulp & Paper Engn, Guangzhou 510640, Guangdong, Peoples R China

年份：2017

卷号：7

期号：5

起止页码：2905-2912

外文期刊名：RSC ADVANCES

收录：;EI(收录号：20170503292834);Scopus(收录号：2-s2.0-85010408632);WOS:【SCI-EXPANDED(收录号:WOS:000393748600060)】；

基金：This work was financially supported by the State Key Laboratory of Tree Genetics and Breeding, State Key Laboratory of Pulp and Paper Engineering (201611), Jiangsu Province Biomass Energy and Materials Laboratory in Institute of Chemical Industry of Forest Products, CAF (JSBEM201601).

语种：英文

摘要：Novel cellulose hydrogels based on the inclusion complex between alpha-cyclodextrin and binary-drug loaded nanoparticles (carboxymethylcellulose-betulinic acid/hydroxycamptothecine nanoparticles) were prepared in aqueous media for the first time. As the reversible supramolecular assembly behavior, the thermosensitive hydrogels showed distinctive reversible gel-sol transition properties related to structure at a particular temperature. The temperature of the gel-sol transition was decided by the concentration between the nanoparticles and a-cyclodextrin. In addition, the injectable drug delivery applications of the BA/HCPT-loaded hydrogel showed more effectively than that of free drugs and BA/HCPT-loaded nanoparticles for in vitro and in vivo studies. Such an injectable hydrogel with a unique structure and temperature responses would be a promising candidate for many intelligent delivery applications.