文献类型：期刊文献

中文题名：葡聚糖基水凝胶的制备及其应用的研究进展

英文题名：Research Progress on Preparation Methods and Applications of Dextran-based Hydrogels

作者：林艳[1,2,3,4] 房桂干[1,2,3,4] 霍丹[1,2,3,4]

第一作者：林艳

通信作者：Fang, Gui-Gan|[a000589b6171897e30b38]房桂干;

机构：[1]中国林业科学研究院林产化学工业研究所;[2]生物质化学利用国家工程实验室;[3]国家林业局林产化学工程重点开放性实验室;[4]江苏省生物质能源与材料重点实验室

年份：2015

卷号：35

期号：6

起止页码：148-152

中文期刊名：林产化学与工业

外文期刊名：Chemistry and Industry of Forest Products

收录：CSTPCD;;EI(收录号：20161202132633);Scopus(收录号：2-s2.0-84960953687);北大核心:【北大核心2014】；CSCD:【CSCD2015_2016】；

基金：“十二五”国家科技支撑计划资助(2014BAD02B02)

语种：中文

中文关键词：葡聚糖;水凝胶;分离;组织工程;药物释放

外文关键词：dextran; hydrogel; separation; tissue engineering ; drug releasing

分类号：TQ35;O629.12

摘要：葡聚糖是一种生物性多糖,主链上含有很多游离的羟基,易于修饰和交联。葡聚糖水凝胶具有良好的溶胀性、生物相容性、生物可降解性,在物质分离、药物缓释和组织工程等领域具有较好的应用前景。论文综述了近年来葡聚糖水凝胶的几种常见的制备方法,即反复冷冻-解冻法、化学交联法、接枝改性法、自由基聚合法,并对其在分离吸附、药物缓释、组织工程、医用材料等方面的应用研究进行综述,同时对其未来发展进行了展望。
As a kind of biological polysaccharide, dextran contains many free hydroxyl groups on the main chain, which is convenient for modification and crosslinking. The hydrogels prepared by dextran exhibited excellent swelling property, biocompatibility and biodegradability. Dextran is widely applied in the fields of substance separation, drug delivery and tissue engineering. Kinds of common preparation methods of dextran-based hydrogels, including repeated freezing-thawing method, chemical crosslinking method, grafting modification method, and free radical polymerization, have been summarized, Besides, the applications of dextran-based hydrogels in recent years are reviewed and the future developments are discussed in present study.