文献类型：期刊文献

英文题名：Synthesis and antitumor activities of unsymmetrically disubstituted acylthioureas fused with hydrophenanthrene structure

作者：Rao, Xiao-Ping[1] Wu, Yong[1] Song, Zhan-Qian[1] Shang, Shi-Bin[1] Wang, Zong-De[1]

第一作者：饶小平

通信作者：Rao, XP[1]|[a0005b2996927fc131f05]饶小平;

机构：[1]Chinese Acad Forestry, Inst Chem Ind Forest Prod, Nanjing 210042, Peoples R China

年份：2011

卷号：20

期号：3

起止页码：333-338

外文期刊名：MEDICINAL CHEMISTRY RESEARCH

收录：;Scopus(收录号：2-s2.0-79958130467);WOS:【SCI-EXPANDED(收录号:WOS:000288398900010)】；

基金：This research was financially supported by grants from National Natural Science Foundation of China (No. 30771690) and Forestry Commonwealth Industry Special Foundation of China (No. 200704008).

语种：英文

外文关键词：Unsymmetrically disubstituted acylthioureas; Hydrophenanthrene structure; Delta(8)-Dihydroabietic acid; Dehydroabietic acid; Antitumor activities

摘要：A series of novel unsymmetrically disubstituted acylthioureas fused with hydrophenanthrene structure were synthesized from Delta(8)-dihydroabietic and dehydroabietic acid, respectively. Their structures were characterized by IR, H-1-, and C-13-NMR spectroscopy. The antitumor activities of the title compounds against SMMC7721 and A549 tumor cells were evaluated by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) method. The results showed that three compounds (4c1, 4d1, and 4d2) exhibited highly effective activities against SMMC7721 and A549 cells, their IC50 values are between 1.87-12.67 mu M for SMMC7721 cells and 2.20-6.79 mu M for A549 cells, respectively. Structure-activity relationship indicating that acylthioureas that furan group fused with Delta(8)-dihydroabietyl group, trihydroxymethyl fused with Delta(8)-dihydroabietyl and dehydroabietyl could generate enhance activities of this kind of compounds against SMMC7721 and A549 cells.