文献类型：期刊文献

英文题名：Lignin-Based Hollow Nanoparticles for Controlled Drug Delivery: Grafting Preparation Using beta-Cyclodextrin/Enzymatic-Hydrolysis Lignin

作者：Zhou, Yu[1,2] Han, Yanming[1] Li, Gaiyun[1] Yang, Sheng[1] Chu, Fuxiang[1]

第一作者：周宇;Zhou, Yu

通信作者：Han, YM[1];Chu, FX[1]|[a0005728d87cb2daf502d]储富祥;

机构：[1]Chinese Acad Forestry, Res Inst Wood Ind, Xiangshan Rd, Beijing 100089, Peoples R China;[2]Yancheng Inst Technol, Sch Chem & Chem Engn, Yancheng City 224051, Peoples R China

年份：2019

卷号：9

期号：7

外文期刊名：NANOMATERIALS

收录：;Scopus(收录号：2-s2.0-85073279508);WOS:【SCI-EXPANDED(收录号:WOS:000478992600085)】；

基金：This study was financially supported by the National Natural Science Foundation of China (31770610) and the National Non-Profit Special Fund for Fundamental Research from the Chinese Academy of Forestry (CAFYBB2017ZX003).

语种：英文

外文关键词：lignin; beta-cyclodextrin; hollow nanoparticles; hydroxycamptothecin; sustained release

摘要：Due to its abundance, degradability, and low toxicity, lignin is a promising raw material for the preparation of nanomaterials. However, efficient encapsulation using lignin-nanomaterial for sustained-release medications remains a challenge. This study involves grafting beta-cyclodextrin (beta-CD), with a hollow toroidal structure, onto the enzymatic-hydrolysis lignin (EHL) to form CD-EHL. The modified lignin was next used to prepare hollow nanoparticles (LHNPs) via self-assembly to encapsulate the antitumor drug hydroxycamptothecin (HCPT). The results indicated that beta-CD improved the network structure of modified lignin molecules. Moreover, LHNPs that self-assembled using CD-EHL had an increased specific surface area and greater porosity, and exhibited a spherical hollow structure and stability in phosphate-buffered saline. The drug loading and encapsulation efficiency of HCPT were 70.6 +/- 9% and 22.02 +/- 2%, respectively. An in vitro study showed that lignin-based nanoparticles have low toxicity, and the modified LHNPs demonstrated a good sustained-release capability. This study broadened the potential application of lignin as a renewable biomass material.