文献类型：期刊文献

英文题名：Green antibiotic breakthrough: Short–rotation woody crops pulp waste liquor defeats drug-resistant bacterial biofilms

作者：Lin, Yan[1] Jiao, Ting[2] Jiao, Jian[2] Zhang, Ming[3] Wang, Wentao[1]

第一作者：Lin, Yan

机构：[1] College of Science, Nanjing Forestry University, Nanjing, 210037, China; [2] National Key Laboratory for Development and Utilization of Forest Food Resources, Institute of Chemical Industry of Forest Products, Chinese Academy of Forestry, Nanjing, 210042, China; [3] The Affiliated Stomatological Hospital of Nanjing Medical University, State Key Laboratory Cultivation Base of Research, Prevention and Treatment for Oral Diseases, Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Nanjing Medical University, Nanjing, 210029, China

年份：2025

卷号：521

外文期刊名：Chemical Engineering Journal

收录：EI(收录号：20253318975703);Scopus(收录号：2-s2.0-105012993465)

语种：英文

外文关键词：Antibiotics - Antimicrobial agents - Bacteria - Composite films - Drug delivery - Pulp - Pulp manufacture - Staphylococcus aureus

摘要：The increasing misuse of antibiotics and the accelerated evolution of drug-resistant bacteria have made antimicrobial resistance a worldwide public health emergency. Natural products emerge as promising alternatives due to their multi-target antibacterial mechanisms, favorable safety, and environmentally friendly properties, but their practical application remains hindered by stability challenges. Pulp waste liquid contains lignin-derived polyphenolic compounds exhibiting intrinsic antibacterial activity and great biocompatibility. In this study, we employed waste liquor from five short-rotation woody crop (SRWC) pulp waste liquors as primary feedstocks to obtain the optimal antimicrobial agent (BHTY0201 WZY-0) through systematic selection and evaluation. The antibacterial experiments revealed that the bactericidal effect of BHTY0201 WZY-0 was mediated by disruption of membrane integrity, enhancement of reactive oxygen species (ROS), and inhibition of biofilm formation. In vivo assessments demonstrated accelerated healing of methicillin-resistant Staphylococcus aureus (MRSA)-infected wounds, accompanied by attenuated inflammatory cytokine levels, with no detectable hemolytic activity or histopathological toxicity. Further engineering of polyvinyl alcohol composite films highlighted its applicability in food preservation systems. This investigation establishes a nature-inspired therapeutic strategy against drug-resistant pathogens while achieving valorization of industrial waste streams, presenting dual advancements in environmental sustainability and biomedical innovation. ? 2025 Elsevier B.V.