文献类型：期刊文献

中文题名：Polymeric Hydrogel Nanocapsules: A Thermo and pH Dual-responsive Carrier for Sustained Drug Release

英文题名：Polymeric Hydrogel Nanocapsules: A Thermo and pH Dual-responsive Carrier for Sustained Drug Release

作者：Jingya Nan[1,2,3,4] Ying Chen[1,2,3,4,5] Rutian Li[6,7] Jifu Wang[1,2,3,4,5] Meihong Liu[1,2,3,4] Chunpeng Wang[1,2,3,4] Fuxiang Chu[8]

第一作者：Jingya Nan

机构：[1]Institute of Chemical Industry of Forest Products, Chinese Academy of Forestry;[2]Key Laboratory of Biomass Energy and Material,Jiangsu Province;[3]National Engineering Laboratory for Biomass Chemical Utilization;[4]Key and Open Laboratory on Forest ChemicalEngineering, SFA;[5]Institute of New Technology, Chinese Academy of Forestry;[6]The Comprehensive Cancer Center, Drum-Tower Hospital of Nanjing University;[7]Clinical Cancer Institute of Nanjing University;[8]Chinese Academy of Forestry

年份：2014

卷号：0

期号：3

起止页码：200-208

中文期刊名：纳微快报：英文版

收录：Scopus;PubMed

基金：financially supported by the National Natural Science Foundation of China (Grant No. 31100427, No. 81101751);the Jiangsu Province Natural Science Foundation (BK20131071)

语种：英文

中文关键词：Hydrogel capsules;Sustained release;High drug loading;Dual responsivity

外文关键词：Hydrogel capsules; Sustained release; High drug loading; Dual responsivity

分类号：TQ460.1

摘要：Hydrogel capsules show attractive prospects in drug delivery recently because of high drug loading and sustained release behavior. In this study we reported a simple and convenient route to fabricate poly(acrylic acid)-poly(N-isopropylacrylamide)(PAA-PNIPAm) hydrogel capsules by using hydroxypropylcellulose-poly(acrylic acid)(HPC-PAA) complexes as the templates. The capsules showed a high drug loading(～280% to the weight of capsules) for Doxorubicin hydrochloride. The release of drug from the capsules was responsive to the temperature and p H of the surroundings, showing a low-rate but sustained release behavior favorable for low-toxic and long-term therapy. Together with the convenient preparation, high drug loading, dual responsivity as well as the sustained release feature, it is implied that this polymeric hydrogel capsule might be a promising candidate for new drug carriers.
Hydrogel capsules show attractive prospects in drug delivery recently because of high drug loading and sustained release behavior. In this study we reported a simple and convenient route to fabricate poly (acrylic acid)-poly (N-isopropylacrylamide) (PAA-PNIPAm) hydrogel capsules by using hydroxypropylcellulose-poly (acrylic acid) (HPC-PAA) complexes as the templates. The capsules showed a high drug loading (similar to 280% to the weight of capsules) for Doxorubicin hydrochloride. The release of drug from the capsules was responsive to the temperature and pH of the surroundings, showing a low-rate but sustained release behavior favorable for low-toxic and long-term therapy. Together with the convenient preparation, high drug loading, dual responsivity as well as the sustained release feature, it is implied that this polymeric hydrogel capsule might be a promising candidate for new drug carriers.