文献类型：期刊文献

中文题名：二氢枯茗酰基硫脲的合成及抑菌活性研究

英文题名：Synthesis and Antibacterial Activity of Dihydrocumatacylthiourea

作者：高艳清[1,2,3,4] 王丹[1,2,3,4,5] 商士斌[1,2,3,4,5] 李健[1,2,3,4]

第一作者：高艳清

机构：[1]中国林业科学研究院林产化学工业研究所;[2]生物质化学利用国家工程实验室;[3]国家林业局林产化学工程重点开放性实验室;[4]江苏省生物质能源与材料重点实验室;[5]中国林业科学研究院林业新技术研究所

年份：2012

卷号：32

期号：3

起止页码：23-27

中文期刊名：林产化学与工业

外文期刊名：Chemistry and Industry of Forest Products

收录：CSTPCD;;Scopus;北大核心:【北大核心2011】；CSCD:【CSCD_E2011_2012】；

语种：中文

中文关键词：β-蒎烯;诺蒎酸;二氢枯茗酸;酰基硫脲衍生物;抑菌

外文关键词：β-pinene ; nopinic acid ; dihydrocumic acid ; acylthiourea derivatives; antibacterial

分类号：TQ351.471

摘要：以β-蒎烯为原料、碱性高锰酸钾为氧化剂合成了诺蒎酸,诺蒎酸酸性脱水并异构开环得到二氢枯茗酸。二氢枯茗酸经过酰氯化、酯化,再与相应的胺反应得到了6种酰基硫脲化合物,通过IR,1H NMR,MS和元素分析对产物进行了结构鉴定,并通过抑菌环法对化合物的抑菌活性进行了测试。测试结果表明,化合物二氢枯茗邻甲苯酰基硫脲(Ⅵc),二氧枯茗间甲苯酰基硫脲(Ⅵd)对大肠杆菌的抑菌圈直径分别是11.33、11.00 mm,高于市售试剂新洁尔灭。
Nopinic acid was synthesized using β-pinene as raw material and potassium permanganate as oxidant. Dihydrocumic acid was obtained after dehydration of nopinic acid. Six kinds of acyhhiourea derivatives were prepared by reactions with SOC12, KSCN and amines. The structure of products was confirmed by IR, ^1H NMR, MS and elemental analysis. The antibacterial ac- tivity of these compounds were tested. It showed that the anti-bacterium zones of compounds VIc and VId were 11.33 and 11.00 mm, respectively, which were bigger than Bromo Geramine.