文献类型：期刊文献

中文题名：新型脱氢松香基季铵盐类抗菌剂的合成、结构表征及抗菌活性研究

英文题名：SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF SOME QUATERNARY AMMONIUM SALTS FROM DEHYDROABIETYLAMINE

作者：王延[1] 杨成根[2] 周永红[1] 宋湛谦[1]

第一作者：王延

机构：[1]中国林业科学研究院林产化学工业研究所;[2]杨州大学农学院

年份：1998

卷号：10

期号：4

起止页码：59-63

中文期刊名：天然产物研究与开发

收录：CSTPCD;;CSCD:【CSCD2011_2012】；

基金：江苏省自然科学基金

语种：中文

中文关键词：脱氢松香胺;季铵盐;抗菌活性;合成;结构表征

外文关键词：Dehydroabietylamine,Quatermary ammonium salts, Antibacterial activity

分类号：TQ463.4

摘要：以天然松香酸衍生物——脱氢松香胺为原料,合成了6种脱氢松香基季铵盐。对合成化合物结构进行了元素分析、紫外、红外光谱及核磁共振谱鉴定。药理实验结果表明,合成产品对金黄色葡萄球菌及大肠杆菌具有一定抗菌活性,其最低抑菌浓度分别为7. 18～31. 25μ/ml和250～500μg/ml。同时对产品结构对抗菌活性影响也进行了比较研究。
Six quaternary ammonium salts were synthesized from dehgdroabietylamine, a important derivitive of natural rosin acids,and identified with elemental analysis,UV,IR and NMR spectra pharmacological tests inducated that these salts possessed some inhibitive activity against S. aureus and E. coli. , The MIC was 7. 81 - 31. 25ug/mL for S. aureus, which was similar with the commercial quaternary ammonium 1227,and 250-500ug/mL for E. coli respectively. It also was found that the ammonium salts with ,N,N-dirmethyl groups had stronger antibacterial activity than these with NN-diethyloxyl groups.