文献类型：期刊文献

中文题名：松针聚戊烯醇的药用价值与开发应用

英文题名：Medicinal value and development of polyprenols from pine needles

作者：郑光耀[1,2,3,4,5] 闫林林[1,2,3,4,5] 谢衡[6]

第一作者：郑光耀

机构：[1]中国林业科学研究院林产化学工业研究所;[2]江苏省生物质能源与材料重点实验室;[3]国家林业局林产化学工程重点开放性实验室;[4]生物质化学利用国家工程实验室;[5]南京林业大学林业资源高效加工利用协同创新中心;[6]中健行集团有限公司

年份：2019

卷号：28

期号：5

起止页码：608-615

中文期刊名：中国新药杂志

外文期刊名：Chinese Journal of New Drugs

收录：CSTPCD;;Scopus;北大核心:【北大核心2017】；CSCD:【CSCD2019_2020】；

基金：国家林业局林业专利产业化推进项目(林业专利2017-1)

语种：中文

中文关键词：松针;聚戊烯醇;提取;药理活性;药物开发

外文关键词：pine needle;polyprenols;extraction;pharmacological activity;drug development

分类号：R965

摘要：松针聚戊烯醇是从松针不皂化的脂溶性物质中提取的长链多萜类化合物,与人体脏器中所含的多萜醇具有相似的生理结构特征,在保护细胞膜、稳定细胞蛋白质和支持人体免疫系统中发挥主要作用,还担当辅酶在多糖合成和蛋白质-碳水化合物新陈代谢中起作用,具有开发成为创新药物的巨大潜能。本文对松针聚戊烯醇的化学结构、提取技术、药用价值及开发应用进行了总结,包括治疗肝脏疾病、阿尔茨海默病、脑缺血、结核病、多发性硬化症、抗病毒活性、降血脂、抗炎活性和保护雄性生育力等药用价值,为我国松针聚戊烯醇产业化开发提供科学参考,促进松针资源的开发利用从传统的粗放型农业产业向现代的高效型生物医药产业转化。
Pine needles polyprenols are long-chain isoprenoid alcohols extracted from unsaponified liposoluble substance of pine needles,which have similar physiological structural characteristics as dolichols in human body organs. They play a major role in protecting cellular membranes,stabilising cell proteins and supporting the body’s immune system. They also act as coenzymes in the synthesis of polysaccharides and in protein-carbohydrate metabolism.Thus,pine needles polyprenols have great value in developing innovative drugs. This paper summarized the chemical structure,extraction technology,medicinal value and development utilization of pine needles polyprenols,including treatment for liver diseases,alzheimer’s disease,cerebral ischemia,tuberculosis,multiple sclerosis,antiviral activity,anti-hyperlipidemia,anti-inflammatory activity and androprotective properties,which provides scientific references for the industrial development of pine needles polyprenols in China,and promote the development and utilization of pine needles from the traditional extensive agriculture industry to the modern efficient biomedicine industry.