文献类型：期刊文献

英文题名：Synthesis and biological activity of pyridine acylhydrazone derivatives of isopimaric acid

作者：Lu, Yan-Ju[1,2,3,4,5,6] Zhao, Zhen-Dong[1,2,3,4,5,6] Chen, Yu-Xiang[1,2,3,4,5,6] Wang, Jing[1,2,3,4,5,6] Xu, Shi-Chao[1,2,3,4,5,6] Gu, Yan[1,2,3,4,5,6]

第一作者：Lu, Yan-Ju;卢言菊

通信作者：Lu, YJ[1];Zhao, ZD[1]

机构：[1]Chinese Acad Forestry, Inst Chem Ind Forest Prod, Nanjing 210042, Peoples R China;[2]Natl Engn Lab Biomass Chem Utilizat, Nanjing 210042, Peoples R China;[3]Natl Forestry & Grassland Adm, Key Lab Chem Engn Forest Prod, Nanjing 210042, Peoples R China;[4]Coinnovat Ctr Efficient Proc & Utilizat Forest Re, Nanjing 210042, Peoples R China;[5]Key Lab Biomass Energy & Mat, Nanjing 210042, Peoples R China;[6]Chinese Acad Forestry, Res Inst Forestry New Technol, Beijing 100091, Peoples R China

年份：2021

卷号：23

期号：6

起止页码：545-555

外文期刊名：JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

收录：;Scopus(收录号：2-s2.0-85089969881);WOS:【SCI-EXPANDED(收录号:WOS:000564533500001)】；

基金：This research was supported by the National Natural Science Foundation of China (grant No. 31700504) and the Fundamental Research Funds of Jiangsu Province Biomass Energy and Materials Laboratory, China (grant No. JSBEM-201808).

语种：英文

外文关键词：Isopimaric acid; pyridine acylhydrazone derivatives of isopimaric acid; biological activity

摘要：Pyridine acylhydrazone derivatives of isopimaric acid were synthesized and characterized. The minimum inhibitory concentrations of the compounds against five bacteria were determined and most of the compounds displayed some degree of antibacterial activity. The results showed that antimicrobial activity againstStreptococcus pneumoniaeimproved when halogen atoms were introduced into the isopimaric acid, especially when one bromine atom was introduced in the para-position of isopimaric acid. Compound isopimaric acid (5-bromo pyridine-2-formaldehyde) acylhydrazone exhibited a significant antitumorial activity against hepatocarcioma cells (HepG-2) and breast cancer cells (MDA-MB-231), with inhibition degrees of 74.21% and 70.39%, respectively, at 100 mu M.