文献类型：期刊文献

英文题名：Antimicrobial and antifouling coating constructed using rosin acid-based quaternary ammonium salt and N-vinylpyrrolidone via RAFT polymerization

作者：Li, Zhaoshuang[1] Wang, Siheng[1] Yang, Xinxin[1] Liu, He[1] Shan, Yu[3] Xu, Xu[2] Shang, Shibin[1] Song, Zhanqian[1]

第一作者：Li, Zhaoshuang

通信作者：Liu, H[1];Song, ZQ[1]|[a0005c3716bb5fed5ea85]宋湛谦;

机构：[1]Chinese Acad Forestry, Inst Chem Ind Forestry Prod,Natl Forestry & Grass, Key Lab Biomass Energy & Mat,Key Lab Chem Engn Fo, Natl Engn Lab Biomass Chem Utilizat,Coinnovat Ctr, Nanjing 210042, Jiangsu, Peoples R China;[2]Nanjing Forestry Univ, Coll Chem Engn, Coinnovat Ctr Efficient Proc & Utilizat Forest Re, Jiangsu Prov Key Lab Chem & Utilizat Agroforest B, Nanjing 210037, Jiangsu, Peoples R China;[3]Jiangsu Prov & Chinese Acad Sci, Inst Bot, Nanjing 210014, Peoples R China

年份：2020

卷号：530

外文期刊名：APPLIED SURFACE SCIENCE

收录：;EI(收录号：20203008965904);Scopus(收录号：2-s2.0-85088151527);WOS:【SCI-EXPANDED(收录号:WOS:000564001300003)】；

基金：The authors express their gratitude for financial support from the Foundation of Jiangsu Province Biomass Energy and Material Laboratory (JSBEM-S-201905), National Natural Science Foundation of China (31570562) and the Discipline Group Construction Project of CAF-ICIFP (LHSXKQ1).

语种：英文

外文关键词：N-vinylpyrrolidone; Maleopimaric acid quaternary ammonium cation; Antimicrobial; Antifouling; Biocompatibility; Coating

摘要：Biofilm formation of pathogenic bacteria on the surfaces of implantable biomedical devices limit their applications and effective usage. Current antimicrobial coatings for implantable biomedical devices have significant deficiencies including a lack of long-term activity and biocompatibility. Herein, a dual-functional coating (antifouling and antimicrobial) was constructed using a combination of N-vinylpyrrolidone (NVP) and maleopimaric acid quaternary ammonium cation containing a double bond functionality (GMA-MPA-N+) via surface-initiated reversible addition-fragmentation chain-transfer polymerization. Scanning electron microscopy, energy-dispersive X-ray spectroscopy, and X-ray photoelectron spectroscopy were used to confirm the successful construction of coating. GMA-MPA-N+ endowed the dual-functional coating with excellent broad-spectrum antimicrobial activities against Gram-positive bacteria (Staphylococcus aureus) and Gram-negative (Escherichia coli, Pseudomonas aeruginosa) bacteria. The biofilm formation on this coating was inhibited for up to 21 days, and protein adsorption and platelet adhesion decreased significantly compared to those on the pristine substrate surfaces. The cytotoxicity assays demonstrated that the coating displayed excellent biocompatibility with the mammalian cells. Notably, the subcutaneous implantation of samples in the rat assay showed the excellent anti infective property of the coating in vivo. Thus, the dual-functional antimicrobial coating exhibited long-term anti-biofilm properties as well as excellent biocompatibility, thereby providing insights into the design of implantable biomedical devices with antimicrobial properties.