文献类型：期刊文献

英文题名：Robust antimicrobial compounds and polymers derived from natural resin acids

作者：Wang, Jifu[1,2,3] Chen, Yung Pin[1,2] Yao, Kejian[1,2] Wilbon, Perry A.[1,2] Zhang, Wujie[4] Ren, Lixia[1,2] Zhou, Juhua[5] Nagarkatti, Mitzi[5] Wang, Chunpeng[3] Chu, Fuxiang[3] He, Xiaoming[4] Decho, Alan W.[1,2] Tang, Chuanbing[1,2]

第一作者：王基夫;Wang, Jifu

通信作者：Tang, CB[1]

机构：[1]Univ S Carolina, Dept Chem & Biochem, Dept Environm Hlth Sci, Columbia, SC 29208 USA;[2]Univ S Carolina, USC Nanoctr, Columbia, SC 29208 USA;[3]Chinese Acad Forestry, Inst Chem Ind Forestry Prod, Nanjing 210042, Jiangsu, Peoples R China;[4]Ohio State Univ, Dept Biomed Engn, Columbus, OH 43210 USA;[5]Univ S Carolina, Sch Med, Dept Pathol Microbiol & Immunol, Columbia, SC 29209 USA

年份：2012

卷号：48

期号：6

起止页码：916-918

外文期刊名：CHEMICAL COMMUNICATIONS

收录：;Scopus(收录号：2-s2.0-84055182861);WOS:【SCI-EXPANDED(收录号:WOS:000299589700041)】；

基金：This work was supported by the University of South Carolina start-up funds, USDA NIFA under the Award 2011-51160-31205, and Forestry Public Sector Research Fund of State Forestry Administration of China (grant number 200804011) and Special Fund for Fundamental Research from Research Institute of New Technology of Chinese Academy of Forestry (CAFINT2010C05 and CAFYBB2010003).

语种：英文

摘要：We report novel robust resin acid-derived antimicrobial agents that exhibit excellent antimicrobial activities against a broad spectrum of bacteria (6 Gram-positive and 7 Gram-negative) with selective lysis of microbial membranes over mammalian membranes. Our results indicate that hydrophobicity and unique structures of resin acids can be determining factors in dictating the antimicrobial activity.