文献类型：期刊文献

中文题名：含氟脱氢枞胺Schiff碱的合成及抑菌活性

英文题名：Synthesis and Antibacterial Activity of Fluorine-containing Schiff Bases Derived from Dehydroabietylamine

作者：饶小平[1,2] 宋湛谦[1,2] 高宏[1,2]

第一作者：饶小平

机构：[1]中国林业科学研究院林产化学工业研究所;[2]国家林业局林产化学工程重点开放性实验室

年份：2007

卷号：27

期号：2

起止页码：97-99

中文期刊名：林产化学与工业

外文期刊名：Chemistry and Industry of Forest Products

收录：CSTPCD;;Scopus;CSCD:【CSCD_E2011_2012】；

语种：中文

中文关键词：取代苯甲醛缩脱氢枞胺;含氟Schiff碱;抑菌活性

外文关键词：substituted benzaldehyde semi-dehydroabietylamine;fluorine-containing Schiff base;antibacterial activity Schiff

分类号：TQ423

摘要：用直接缩合法合成了含氟的取代苯甲醛缩脱氢枞胺Schiff碱,用IR、1HNMR光谱确证其结构。对含氟Schiff碱进行体外抑菌活性试验。结果表明,含氟的取代苯甲醛缩脱氢枞胺Schiff碱对金黄色葡萄球菌和枯草芽孢杆菌等多种细菌有较强的抑制作用。对氟苯甲醛缩脱氢枞胺Schiff碱对金黄色葡萄球菌以及枯草芽孢杆菌的抑制作用最强,抑菌圈直径分别达到1.65和1.30cm;氟的引入对大肠杆菌无效,抑制能力反而降低。
Fluorine-containing substituted benzaldehyde semi-dehydroabietylamine Schiff bases were synthesized by direct condensation, and their structures were characterized by IR and ^1H NMR spectroscopy. The antibacterial activities of fluorine-containing Schiff bases were tested by extracorporeal experiments. It has been found that fluorine-containing substituted benzaldehyde semi-dehydroabietylamine Schiff bases displayed strong antibacterial activities against many kinds of bacteria such as Staphylococcus aureus and Bacillus subtilis, p-F-substituted benzaldehyde semi-dehydroabietylamine Schiff base has the strongest activity against S. aureus, and B. subtilis. The diameters of antibacterial rings reached 1.65 and 1.30 cm, respectively. The introduction of fluorine atom in Schiff base was ineffective against Escherichia coli, the activity was even reduced.