文献类型：期刊文献

英文题名：Synthesis and quantitative structure-activity relationship (QSAR) studies of novel rosin-based diamide insecticides

作者：Li, Jian[1] Gao, Yanqing[2] Shang, Shibin[3] Rao, Xiaoping[3] Song, Jie[4] Wang, Zongde[5]

第一作者：Li, Jian

通信作者：Li, J[1]

机构：[1]Northwest Agr & Forestry Univ, Coll Forestry, Yangling 712100, Shaanxi, Peoples R China;[2]Northwets Agr & Forestry Univ, Coll Plant Protect, Res & Dev Ctr Biorat Pesticide, Yangling 712100, Shaanxi, Peoples R China;[3]Chinese Acad Forestry, Inst Chem Ind Forest Prod, Nanjing 210042, Jiangsu, Peoples R China;[4]Univ Michigan, Dept Chem & Biochem, Flint, MI 48502 USA;[5]Jiangxi Agr Univ, Coll Forestry, Nanchang 330045, Jiangxi, Peoples R China

年份：2014

卷号：4

期号：102

起止页码：58190-58199

外文期刊名：RSC ADVANCES

收录：;EI(收录号：20144800261250);Scopus(收录号：2-s2.0-84911877574);WOS:【SCI-EXPANDED(收录号:WOS:000345460800010)】；

基金：This work was supported by the National Natural Science Foundation of China (Project no. 31400509 and Project no. 31401783), Forestry Industry Research Special Funds for Public Welfare Projects (Project no. 201404701) and Research Fund for the Doctoral Program of Higher Education of Northwest A&F University (Project no. 2013BSJJ048).

语种：英文

外文关键词：Insecticides - Mammals - Regression analysis - Structures (built objects)

摘要：In a continuing effort to develop novel natural product-based insecticidal agents endowed with low mammalian toxicity, two series of rosin-based diamides have been synthesized, and their insecticidal activities against Plutella xylostella and Mythimna separata were evaluated. Most of the synthesized compounds exhibited moderate to significant insecticidal activity. Among them, thiadiazole-containing diamides 6a-n displayed better activity than others, especially compounds 6f and 6n which exhibited excellent insecticidal activity against P. xylostella, with LC50 values of 0.223 and 0.214 mg L-1, respectively, which approximate to, or are lower than that of, the control flubendiamide (0.222 mg L-1). The preliminary structure-activity relationship analysis indicated that rosin-based diamides with electron-withdrawing groups on the benzene ring showed better insecticidal activity than those with electron-donating groups. Via a best multilinear regression analysis, the generated quantitative structure-activity relationship (QSAR) model (R-2 = 0.9566) revealed a strong correlation of insecticidal activity against P. xylostella with molecular structures of these compounds. These consequences can be expected to instruct the design and development of new rosin-based insecticides.