文献类型：期刊文献

英文题名：Hollow poly(N-isopropylacrylamide)-co-poly(acrylic acid) microgels with high loading capacity for drugs

作者：Chen, Ying[1,2] Chen, Yongbing[3] Nan, Jingya[1] Wang, Chunpeng[1] Chu, Fuxiang[1]

第一作者：陈莹

通信作者：Chen, Y[1]

机构：[1]Chinese Acad Forestry, Inst Chem Ind Forest Prod, Nanjing 210042, Jiangsu, Peoples R China;[2]Chinese Acad Forestry, Inst New Technol, Beijing 100091, Peoples R China;[3]Soochow Univ, Dept Cardiothorac Surg, Affiliated Hosp 2, Suzhou 215004, Peoples R China

年份：2012

卷号：124

期号：6

起止页码：4678-4685

外文期刊名：JOURNAL OF APPLIED POLYMER SCIENCE

收录：;EI(收录号：20121214870853);Scopus(收录号：2-s2.0-84858285977);WOS:【SCI-EXPANDED(收录号:WOS:000301224500034)】；

基金：Contract grant sponsor: State Forestry Administration of China (Forest Public Sector Research Fund); contract grant number: 201104004.; Contract grant sponsor: Institute of New Technology of Chinese Academy of Forestry (Special Fund for Fundamental Research); contract grant number: CAFINT 2010C06.

语种：英文

外文关键词：microgels; drug carriers; high drug loading; pH sensitive; thermosensitive

摘要：A convenient approach has been developed for the preparation of microsize hydrogels composed of crosslinked poly(acrylic acid) (PAA) and poly(N-isopropylacrylamide) (PNIPAm). First, semi-interpenetration polymer networks of hydropropylcellulose (HPC) and PNIPAm-co-PAA copolymer are formed through the copolymerization and crosslinking of monomer acrylic acid and N-isopropylacrylamide in HPC aqueous solution. After the selective removal of HPC from networks due to ionization of PAA units and disruption of hydrogen bonding with increasing pH, PNIPAm-co-PAA microgels are obtained, whose volume is confirmed to be responsive to both temperature and pH. Doxorubicin hydrochloride (Dox) can be encapsulated in PNIPAm-co-PAA microgels with high drug loading driven by the electrostatic interaction, and a sustained-release characteristic of Dox from the microgels is observed under physiological pH value and temperature. In vitro cell experiments, the drug-loaded microgels can be taken up by LoVo cells and release their payload in cell cytoplasm without loss of drug efficacy. This indicates that PNIPAm-co-PAA microgels might be a potential drug delivery carriers especially for water-soluble or polypeptide drugs. (c) 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2011