文献类型：期刊文献

英文题名：Integrating morphology, physiology, and computer simulation to reveal the toxicity mechanism of eco-friendly rosin-based pesticides

作者：Xu, Renle[1] Lou, Yuhang[1] Gao, Yanqing[2] Shang, Shibin[3] Song, Zhanqian[3] Huang, Kerang[4] Li, Luqi[4] Chen, Lei[4] Li, Jian[1]

第一作者：Xu, Renle

机构：[1] College of Forestry, Northwest A&F University, Shaanxi, Yangling, 712100, China; [2] College of Plant Protection, Northwest A&F University, Shaanxi, Yangling, 712100, China; [3] Institute of Chemical Industry of Forest Products, Chinese Academy of Forestry, Jiangsu, Nanjing, 210042, China; [4] Division of Laboratory Safety and Services, Northwest A&F University, Shaanxi, Yangling, 712100, China

年份：2024

卷号：369

外文期刊名：Chemosphere

收录：EI(收录号：20244917469773)

语种：英文

外文关键词：Natural rosin; Pesticides; Toxicity mechanism; Valsa mali, Zebrafish

摘要：To mitigate the impact of traditional chemical pesticides on environment, and achieve sustainable crop protection, 24 eco-friendly rosin-based sulfonamide derivatives were synthesized and developed. The in vitro activity assessment showed that compound 4X (Co. 4X) exhibited excellent fungicidal activity against V. mali (EC50 = 1.106 μg/mL), marginally surpassing the positive control carbendazim (EC50 = 1.353 μg/mL). In vivo investigations suggested that Co. 4X exhibited moderate efficacy in mitigating V. mali infection in both apple trees and apples. Physiological assessments revealed that Co. 4X induced severe ultrastructural damage to the mycelium, heightened cell membrane permeability, and inhibited SDH protein activity. Subsequent biosafety evaluations affirmed the environment-friendly of Co. 4X on Zebrafish (LC50(96h) = 25.176 μg/mL). Toxicological research revealed that Co. 4X caused damage to the cells of Zebrafish gills, liver, and intestines, resulting in impaired respiratory, detoxification, digestion, and absorption functions of Zebrafish. In summary, the findings of this study contribute to a deeper understanding of the toxicity mechanisms of novel pesticides, decreasing environmental risks caused by traditional chemical pesticides, and improving the effective management of novel pesticide applications. ? 2024 Elsevier Ltd