文献类型：期刊文献

英文题名：Bio-inspired nanocomposite by layer-by-layer coating of chitosan/hyaluronic acid multilayers on a hard nanocellulose-hydroxyapatite matrix

作者：Huang, Chen[1,2,3] Fang, Guigan[1] Zhao, Yangyang[4] Bhagia, Samarthya[3] Meng, Xianzhi[3] Yong, Qiang[2] Ragauskas, Arthur J.[3,5,6]

第一作者：Huang, Chen;黄晨

通信作者：Fang, GG[1];Ragauskas, AJ[2]|[a000589b6171897e30b38]房桂干;

机构：[1]Chinese Acad Forestry, Inst Chem Ind Forest Prod, Nanjing 210042, Jiangsu, Peoples R China;[2]Nanjing Forestry Univ, Coinnovat Ctr Efficient Proc & Utilizat Forest Re, Nanjing 210037, Jiangsu, Peoples R China;[3]Univ Tennessee, Dept Chem & Biomol Engn, Knoxville, TN 37996 USA;[4]Univ Tennessee, Dept Mat Sci & Engn, Knoxville, TN 37996 USA;[5]Univ Tennessee, Inst Agr, Ctr Renewable Carbon, Knoxville, TN 37996 USA;[6]Oak Ridge Natl Lab, Biosci Div, Joint Inst Biol Sci, Oak Ridge, TN 37831 USA

年份：2019

卷号：222

外文期刊名：CARBOHYDRATE POLYMERS

收录：;EI(收录号：20192707146618);Scopus(收录号：2-s2.0-85068253807);WOS:【SCI-EXPANDED(收录号:WOS:000475425500009)】；

基金：The authors thank the Innovative Ability Enhancement Project for R&D Team of ICIFP, CAF (LHSXKQ8) and the Fundamental Research Funds of CAF "Enhancing Project in the Field of Wood Composite Materials and Chemical Resources Utilization (CAFYBB2017ZX003-08) for supporting the work presented in this paper. Also, we are grateful to the Advanced Microscopy and Imaging Center, and Joint Institute of Advanced Materials (JIAM) at the University of Tennessee, Knoxville, for providing instruments and facilities for SEM, AFM and TEM imaging.

语种：英文

外文关键词：CNCs/HAP matrix; LBL assembly; Chitosan; Hyaluronic acid

摘要：This study proposed a layer-by-layer technique on the hard CNCs/hydroxyapatite (HAP) matrix using biodegradable and biocompatible chitosan and hyaluronic acid (HA). Inspired by the mineralized collagen in human bone, the CNCs/HAP matrix was synthesized by a facile in situ HAP coating on the CNCs fibers. The chemical and crystalline structure of the CNCs/HAP matrix was investigated with FTIR, XRD, HRTEM, and SAED. The surface of the CNCs/HAP matrix was analyzed by AFM which showed a flat structure with a roughness of 23.12 nm, however, the surface roughness increased to 56.09 nm with the assembly of chitosan and HA. After the LBL assembly, the surface hydrophilicity of the CNCs/HAP films was improved. Moreover, the CNCs/HAP matrix showed enhanced mechanical property than pure CNCs matrix. Although there is compromise in the mechanical property after the LBL assembly, it is anticipated its bioaffinity and biocompatibility will increase with the incoporation of chitosan and HA.