文献类型：期刊文献

英文题名：Poly (Thioether-Polyesters) Micelles Encapsulation Induces ROS-Triggered Targeted Release of Tangeretin

作者：Tan, Bozhan[1,2] Qi, Zhiwen[3] Yang, Guliang[1] Zhong, Haiyan[1]

第一作者：Tan, Bozhan

通信作者：Zhong, HY[1];Qi, ZW[2]

机构：[1]Cent South Univ Forestry & Technol, Food Sci & Engn Coll, Natl Engn Lab Rice & Prod Proc, Changsha 410004, Hunan, Peoples R China;[2]Hunan Changkang Ind Co LTD, Yueyang, Hunan, Peoples R China;[3]Chinese Acad Forestry, Inst Chem Ind Forest Prod, Nanjing 210042, Jiangsu, Peoples R China

年份：2022

卷号：17

期号：3

外文期刊名：NATURAL PRODUCT COMMUNICATIONS

收录：;Scopus(收录号：2-s2.0-85126670148);WOS:【SCI-EXPANDED(收录号:WOS:000772214400001)】；

基金：This study was supported by the key scientific research projects of Natural Science Foundation of Hunan Province (No. 2021JJ31154) and the National Nonprofit Institute Research Grant of CAFINT, China (No. CAFYBB2018GA001).

语种：英文

外文关键词：tangeretin; ROS-responsive; thioether polyesters; solubility; bioavailability

摘要：Tangeretin (Tan) possesses great anti-oxidation and anti-inflammation bioactivities; however, it is accompanied by poor water solubility, which leads to inefficient cellular internalization. To address this issue, a reactive oxygen species (ROS)-triggered poly (thioether-polyesters) micelle (PDHP, PEG-DTT) was designed and prepared via self-assembly, which consisted of poly (thioether-polyesters) as the hydrophilic shell, and the drug Tan as the hydrophobic inner core. The micelles (Tan@ PDHP), with a 63.15% loading efficiency of Tan, showed negligible cytotoxicity, high stability in phosphate-buffered saline buffer (pH = 7.4), and continuous release of Tan with the stimulation of H2O2. In addition, this Tan loading micelle was more efficient in responding to the formation of ROS in the lipopolysaccharide-stimulated RAW264.7 cells compared to that of the free Tan. In short, the strategy of encapsulating the low solubility Tan in ROS-triggered poly (thioether-polyesters) micelles provides an effective assay of enhancing Tan's antioxidative activity.