文献类型：期刊文献

英文题名：Coconut-shell-derived activated carbon for NIR photo-activated synergistic photothermal-chemodynamic cancer therapy

作者：Wu, Gang[1] Jiang, Bao[1] Zhou, Lin[1] Wang, Ao[2] Wei, Shaohua[1,3]

第一作者：Wu, Gang

通信作者：Wei, SH[1];Wang, A[2];Wei, SH[3]

机构：[1]Nanjing Normal Univ, Key Lab Appl Photochem, Jiangsu Collaborat Innovat Ctr Biomed Funct Mat, Coll Chem & Mat Sci,Jiangsu Key Lab Biofunct Mat, Nanjing 210023, Peoples R China;[2]Chinese Acad Forestry, Inst Chem Ind Forest Prod, Nanjing 210042, Peoples R China;[3]Yancheng Inst Technol, Sch Chem & Chem Engn, Yancheng 224051, Peoples R China

年份：2021

卷号：9

期号：10

起止页码：2447-2456

外文期刊名：JOURNAL OF MATERIALS CHEMISTRY B

收录：;EI(收录号：20211210115512);Scopus(收录号：2-s2.0-85102768763);WOS:【SCI-EXPANDED(收录号:WOS:000629733200009)】；

基金：This research was financially supported by the National Natural Science Foundation of China (No. 21671105), the project BZ 201905 supported by new technology and method from scientific instrument and equipment sharing service platform in Jiangsu Province of China, the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD), the Foundation of Jiangsu Collaborative Innovation Centre of Biomedical Functional Materials, and the Natural Science Foundation of Jiangsu Province (BK20180154).

语种：英文

外文关键词：Activated carbon - Diagnosis - Diseases - Hydrogen peroxide - Magnetic resonance imaging

摘要：Exploiting new non-metal-based peroxidase-mimic nanoenzymes for chemodynamic therapy (CDT) in cancer treatment is an active and challenging field. Here, we found that activated carbon nanoparticles (denoted as ANs) fabricated from coconut shell have satisfactory peroxidase-mimic nanoenzyme activity. Based on this positive result, gadodiamide, a clinically used nuclear magnetic imaging contrast agent, was loaded inside the AN pores and encapsulated by polyvinylpyrrolidone (PVP) to obtain Gd@PANs. PANs (ANs modified using PVP) efficiently catalyze the massive decomposition of endogenous hydrogen peroxide (H2O2) inside cancer cells to produce toxic oxidized hydroxyl radicals (OH) for the CDT treatment of cancer, but they showed no toxicity toward normal cells. Additionally, under 808 nm laser irradiation, the photothermal conversion efficiency of the PANs reaches 45.20%, ensuring their effective photothermal therapy (PTT) treatment functionality. Simultaneously, during PTT treatment, the heating effect significantly enhances the peroxidase-mimic activity of the PANs to achieve an ideal PTT-CDT synergistic therapeutic outcome. Gd@PANs can also be used for the T1-magnetic resonance imaging (MRI) of tumors to integrate treatment and diagnosis.