文献类型：期刊文献

英文题名：Microwave-assisted synthesis of nutgall tannic acid-based salecan polysaccharide hydrogel for tunable release of beta-lactoglobulin

作者：Hu, Xinyu[1,2,3,4,5] Yan, Linlin[1] Wang, Yongmei[1] Xu, Man[1]

第一作者：胡新宇;Hu, Xinyu

通信作者：Hu, XY[1]|[a0005881e11db1c0efa81]胡新宇;

机构：[1]Chinese Acad Forestry, Key Lab Biomass Energy & Mat, Inst Chem Ind Forestry Prod, Nanjing 210042, Jiangsu, Peoples R China;[2]Chinese Acad Forestry, Res Inst Forestry New Technol, Beijing 100091, Peoples R China;[3]Coinnovat Ctr Efficient Proc & Utilizat Forest Re, Nanjing 210042, Jiangsu, Peoples R China;[4]Natl Forestry & Grassland Adm, Key Lab Chem Engn Forest Prod, Beijing 100714, Peoples R China;[5]Natl Engn Lab Biomass Chem Utilizat, Nanjing 210042, Peoples R China

年份：2020

卷号：161

起止页码：1431-1439

外文期刊名：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

收录：;EI(收录号：20241015685564);Scopus(收录号：2-s2.0-85089354431);WOS:【SCI-EXPANDED(收录号:WOS:000571204500010)】；

基金：Thisworkwas supported by the National Key R&D Program of China under the Grant 2018YFD0600400, the Fundamental Research Funds of CAF under the Grant CAFYBB2020QB007, the National Natural Science Foundation of China under the Grant 31700500 and the Key Lab. of Biomass Energy and Material, Jiangsu Province (KLBEM) under the Grant JSBEM-S-201904. We thank LetPub (www.letpub.com) for its linguistic assistance during the preparation of this manuscript.

语种：英文

外文关键词：beta-lactoglobulin; Salecan; Microwave-assisted polymerization; Targeted release in SIP; Release mechanism; Protein delivery

摘要：The low stability of beta-lactoglobulin (beta lg) under gastric conditions decreases the protein amount reaching the small intestine. Thus, it is crucial to develop a vehicle that can protect beta lg from the stomach harsh acidity and enable its sustained and prolonged release in the small intestine. Herein, a fresh hydrogel composed of salecan-g-poly(N,N-dimethylaminoethyl acrylate) (PDMAEA) and nutgall tannic acid (TA) was fabricated by microwave-assisted polymerization. The incorporation of salecan into hydrogels markedly affected the hydrogels' thermal stability, microstructure, and mechanical strength. Particularly, the multiple phenolic groups of TA can form complexes with beta lg, and this enables the highly effective loading of proteins. As expected, beta lg not only achieved effective entrapment into the hydrogels but also achieved a tunable and pH-controlled release. Such a release profile will enable beta lg protection in the stomach and its targeted release in the small intestine. Increasing the salecan content dramatically enhanced the beta lg release in simulated intestinal fluid (SIF). Furthermore, the beta lg release was driven by Fickian diffusion in simulated gastric fluid (SGF), but the mechanism changed to non-Fickian diffusion in SIF. The release mechanism excellently matched Ritger-Peppas model. Overall, these results indicate that TA/salecan-g-PDMAEA hydrogels hold great potential for protein delivery in the gastrointestinal tract. (C) 2020 Elsevier B.V. All rights reserved.