文献类型：期刊文献

英文题名：Cellulose-based polymeric emulsifier stabilized poly(N-vinylcaprolactam) hydrogel with temperature and pH responsiveness

作者：Yang, Xinxin[1,2] Li, Zhaoshuang[1] Liu, He[1] Ma, Lina[3] Huang, Xujuan[4] Cai, Zhaosheng[4] Xu, Xu[2] Shang, Shibin[1] Song, Zhanqian[1]

第一作者：Yang, Xinxin

通信作者：Liu, H[1];Xu, X[2];Ma, LN[3]

机构：[1]Chinese Acad Forestry, Inst Chem Ind Forestry Prod, Key Lab Biomass Energy & Mat, Key Lab Chem Engn Forest Prod,CoInnovat Ctr Effic, Nanjing 210042, Jiangsu, Peoples R China;[2]Nanjing Forestry Univ, Jiangsu Prov Key Lab Chem & Utilizat Agoforest, Adv Anal & Testing Ctr, Coll Chem Engn, Nanjing 210037, Jiangsu, Peoples R China;[3]Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Electroanalyt Chem, Changchun 130022, Peoples R China;[4]Yancheng Inst Technol, Sch Chem & Chem, Yancheng 221051, Jiangsu, Peoples R China

年份：2020

卷号：143

起止页码：190-199

外文期刊名：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

收录：;EI(收录号：20240915629365);Scopus(收录号：2-s2.0-85076239155);WOS:【SCI-EXPANDED(收录号:WOS:000515212500020)】；

基金：This work was supported by the Fundamental Research Funds of CAF [CAFYBB2017QB007], Dongguan Academician Workstation Project [DGYSZ-2017-294].

语种：英文

外文关键词：Responsiveness; Cellulose-based emulsifier; Drug release

摘要：N-vinylcaprolactam (NVCL) is a temperature-responsive monomer, which is widely used for preparing responsive hydrogels. However, poor water solubility of NVCL necessitates the use of emulsifiers for better dispersion. Hydrolyzed epoxy soybean oil -grafted hydroxyethyl cellulose (H-ESO-HEC) polymeric emulsifier has excellent emulsifying properties, and the carboxyl groups afford pH-responsiveness to the hydrogels. A novel temperature- and pH-responsive cellulose-based hydrogel was prepared by combining NVCL and H-ESO-HEC. The hydrogel morphology, thermal stability, and swelling capacity were characterized, and it was also used as a dual-responsive drug preservative carrier. Scanning electron microscopy and thermogravimetric analysis confirmed the porous structure and good thermal stability, respectively, of the hydrogel. The hydrogel displayed a temperature- and pH-dependent swelling behavior and improved swelling capacity. The swelling behavior agreed well with the Korsmeyer-Peppas model and Schott's second-order kinetic model. The dual-responsive hydrogel has significant potential in the drug delivery systems owing to its biocompatibility and temperature and pH sensitivity. (C) 2019 Elsevier B.V. All rights reserved.