文献类型：期刊文献

中文题名：鼠尾草酸的抗氧化活性及抑菌活性研究

英文题名：Study on Antioxidant and Antibacterial Activities of Carnosic Acid

作者：夏田娟[1,2] 毕良武[1,2,3] 赵振东[1,2,3] 邢雅丽[1,2] 程贤[1,2]

第一作者：夏田娟

机构：[1]中国林业科学研究院林产化学工业研究所 生物质化学利用国家工程实验室;[2]国家林业局林产化学工程重点开放性实验室江苏省生物质能源与材料重点实验室;[3]中国林业科学研究院林业新技术研究所

年份：2015

卷号：27

期号：1

起止页码：35-40

中文期刊名：天然产物研究与开发

外文期刊名：Natural Product Research and Development

收录：CSTPCD;;北大核心:【北大核心2014】；CSCD:【CSCD2015_2016】；

基金：引进国际先进林业科学技术项目(2011-4-01)

语种：中文

中文关键词：鼠尾草酸;抗氧化活性;抑菌活性

外文关键词：carnosic acid; antioxidant activity; antibacterial activity

分类号：TQ351.0

摘要：通过自由基清除能力、还原力和平板二倍稀释法实验,评价了鼠尾草酸的抗氧化活性、抑菌活性。结果显示:相同浓度的鼠尾草酸抗氧化活性明显高于合成抗氧化剂PG、BHT、BHA、VE,略低于THBQ,其清除DPPH的IC50值为2.53μg/m L,清除ABTS的IC50值为51.58μg/m L。抑菌实验表明:鼠尾草酸具有广谱抗菌性,特别是大肠埃希氏杆菌、绿脓假单胞菌,其最低抑菌浓度分别为4、<2μg/m L,表现出了比新洁尔灭、氨苄青霉素钠、红霉素更好的抑菌活性;对于肺炎克雷伯氏菌,则表现出了与红霉素同样的抑菌效果,优于新洁尔灭和氨苄青霉素钠。
The antioxidant and antibacterial activities of carnosic acid were studied by radical scavenging effect,reducing ability and tablet dilution methods. The results showed that,the antioxidant activity of carnosic acid was significantly higher than that of synthetic antioxidants PG,BHT,BHA,VE under the same concentration,while slightly lower than THBQ. At the same time,IC50 s of scavenging DPPH and ABTS radical of carnosic acid were 2. 53 μg/m L and 51. 58 μg /m L,respectively. Antibacterial tests indicated that carnosic acid had broad-spectrum of antibacterial activity. Especially for Escherichia coli and Pseudomonas aeruginosa,the MICs of carnosic acid were 4 and 2 μg/m L,better than that of bromogeramine,sodium ampicillin and erythromycin. Moreover,for Klebsiella pneumonia,carnosic acid showed the same inhibitory effect with erythromycin,better than bromogeramine and sodium ampicillin.