文献类型：期刊文献

英文题名：Synthesis, Structure Analysis and Cytotoxicity Studies of Novel Unsymmetrically N,N '-Substituted Ureas from Dehydroabietic Acid

作者：Rao, Xiaoping[1] Song, Zhanqian[1] He, Ling[2] Jia, Weihong[1]

第一作者：饶小平

通信作者：Rao, XP[1]|[a0005b2996927fc131f05]饶小平;

机构：[1]Chinese Acad Forestry, Inst Chem Ind Forest Prod, Nanjing 210042, Peoples R China;[2]China Pharmaceut Univ, Dept Pharmacol, Nanjing 210009, Peoples R China

年份：2008

卷号：56

期号：11

起止页码：1575-1578

外文期刊名：CHEMICAL & PHARMACEUTICAL BULLETIN

收录：;Scopus(收录号：2-s2.0-55749111349);WOS:【SCI-EXPANDED(收录号:WOS:000260521600011)】；

基金：This research was financially supported by grants from Forestry Commonwealth Industry Special Foundation of China (No. 200704008) land National Natural Science Foundation oh China (No. 30771690).

语种：英文

外文关键词：unsymmetrically N,N '-substituted urea; dehydroabietic acid; crystal structure; cytotoxicity activity

摘要：A series of novel unsymmetrically N,N'-substituted ureas were synthesized from dehydroabietic acid and their structures were characterized by IR, H-1-NMR, C-13-NMR spectroscopy and single crystal X-ray diffraction. Three six-membered rings of urea 4c exhibited plane, half-chair anti chair configurations, respectively. Their cytotoxicity activities against SMMC7721 liver cancer cells were evaluated by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) method. The results showed that the title compounds exhibited highly effective cytotoxicity activities against SMMC7721 cells. Their IC50 values are between 8.8 and 14.2 mu mol/l. The change of N' substituted groups resulted little difference to the cytotoxicity activities of ureas, which indicated that the cytotoxicity of this kind of ureas depend strongly on the tricyclic hydrophenanthrene structure.