文献类型：期刊文献

英文题名：Synthesis and antitumor activity of novel alpha-aminophosphonates from diterpenic dehydroabietylamine

作者：Rao, Xiaoping[1] Song, Zhanqian[1] He, Ling[2]

第一作者：饶小平

通信作者：Rao, XP[1]|[a0005b2996927fc131f05]饶小平;

机构：[1]Chinese Acad Forestry, Inst Chem Ind Forest Prod, Nanjing 210042, Peoples R China;[2]China Pharmaceut Univ, Dept Pharmacol, Nanjing 210009, Peoples R China

年份：2008

卷号：19

期号：5

起止页码：512-516

外文期刊名：HETEROATOM CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000257785800013)】；

语种：英文

摘要：A series of novel a-aminophosphonates were synthesized from diterpenic dehydroabietylamine, and their structures were characterized by IR, H-1 NMR, and P-31 NMR spectroscopy. Their antitumor activities against SMMC7721 liver cancer cells were evaluated by the MTT method. Compounds 4 and 6 exhibited higher activities even at vety low concentrations, and the inhibition ratios reached 75% and 79% at 0. 1 mu M, respectively. The inhibition ratio of compound 9 reached 99% after 72-h incubation. aAminophosphonates with a fluorine atom and a nitro group fused to the benzene ring exhibited higher activities. (c) 2008 Wiley Periodicals, Inc.