文献类型：期刊文献

英文题名：Comparative study of injectable and stimuli-responsive hydrogels reinforced with cellulose nanofibers and chitosan for controlled drug delivery

作者：Liang, Yaoting[1] Luo, Tong[2] Li, Feiyun[1] Wang, Jifu[2] Tang, Yanjun[1]

第一作者：Liang, Yaoting

通信作者：Tang, YJ[1]

机构：[1]Zhejiang Sci Tech Univ, State Key Lab Biobased Fiber Mat, Hangzhou 310018, Peoples R China;[2]Chinese Acad Forestry, Inst Chem Ind Forest Prod, Nanjing 210042, Peoples R China

年份：2025

卷号：525

外文期刊名：CHEMICAL ENGINEERING JOURNAL

收录：;EI(收录号：20254519477363);Scopus(收录号：2-s2.0-105021021336);WOS:【SCI-EXPANDED(收录号:WOS:001620342700005)】；

基金：This work was financially supported by National Natural Science Foundation of China (No. 22378367, No. 22078306) , "Pioneer" and "Leading Goose" R & D Program of Zhejiang Province (No. 2023C03157, 2025C02204) , Ningbo Technological Innovation 2025 Project (No. 2022Z101, No. 2023Z142) , and 521 Talent Cultivation Program of Zhejiang Sci-Tech University (No. 11110132521310) .

语种：英文

外文关键词：Cellulose nanofiber; Chitosan; Hydrogel; Metal coordination; Drug delivery

摘要：Hydrogels have been widely explored in biomedical applications due to their soft tissue-like mechanical and tunable properties. However, conventional hydrogels often suffer from inadequate strength, rapid degradation, and limited responsiveness to environmental stimuli, restricting their clinical performance. This study aimed to develop hydrogels reinforced with two types of polysaccharides-rigid, high-strength cellulose nanofibers (CNFs) and pH-responsive chitosan, and to compare their effects on the structural, mechanical, and drug-release performance. Within the polyethylene glycol/sodium acrylate matrix, the incorporation of either CNFs or chitosan enhanced the networks of the resulting hydrogels. Compared to CNFs-composite hydrogels, chitosan-composite hydrogels exhibited a higher swelling ratio (600 %) and enhanced degradation resistance (retaining 30.6 % of mass after 72 h). Moreover, the rheological analysis revealed rapid post-strain recovery and shear-thinning behavior, confirming the injectability and controlled drug-release capability of the hydrogels. The CNFscomposite hydrogels showed pH-dependent release behavior for rhodamine B with faster release at pH 9 (release >89.6 % over 21 days), while the chitosan-composite hydrogels showed more consistent release across pH conditions, demonstrating only 75 % release over the same period. These results demonstrated that both polysaccharides effectively enhanced the hydrogels for potential applications in drug delivery, wound healing and other biomedical fields.