文献类型：期刊文献

英文题名：Comet-like Co-MOF with TiO2 nanoparticles decorated used to efficiently activate peroxymonosulfate for larotrectinib degradation through radical and non-radical pathways

作者：Wang, Hui[1] Chen, Long[2] Yang, Xudong[2] Pan, Fei[3] Sun, Weiliang[2] Li, Fan[2] Duan, Jun[2] Jiang, Chunqian[4] Liu, Wen[2,3,5]

第一作者：王辉

通信作者：Chen, L[1];Liu, W[1]

机构：[1]Chinese Acad Forestry, Key Lab Tree Breeding & Cultivat, Natl Forestry & Grassland Adm, Res Inst Forestry, Beijing 100091, Peoples R China;[2]Peking Univ, Coll Environm Sci & Engn, Key Lab Water & Sediment Sci, Minist Educ, Beijing 100871, Peoples R China;[3]Wuhan Text Univ, Engn Res Ctr Clean Prod Text Dyeing & Printing, Sch Environm Engn, Minist Educ, Wuhan 430073, Peoples R China;[4]Chinese Acad Forestry, Res Inst Forestry, Beijing 100091, Peoples R China;[5]Peking Univ, Natl Lab Mol Sci, Beijing 100871, Peoples R China

年份：2025

卷号：353

外文期刊名：SEPARATION AND PURIFICATION TECHNOLOGY

收录：;EI(收录号：20242516290437);Scopus(收录号：2-s2.0-85196288918);WOS:【SCI-EXPANDED(收录号:WOS:001345319100001)】；

基金：This work was financially supported by the National Natural Science Foundation of China (NSFC) (Nos. 52270053, 52200083 and 52200084) , the National Key Research and Development Program of China (Nos. 2021YFA1202500 and 2022YFF1303004) , the Beijing Natural Science Foundation (No. 8232035) , the Beijing Nova Program (No. 20220484215) , the Beijing National Laboratory for Molecular Sciences (BNLMS2023011) , the China Postdoctoral Science Foundation (No. 2021 M700213) , and Emerging Engineering Interdisciplinary-Young Scholars Project (Peking University) , the Fundamental Research Funds for the Central Universities are greatly acknowledged. DFT calculations supported by the High-Performance Computing Platform of Peking University and the National Key Scientific and Technological Infrastructure project "Earth System Numerical Simulation Facility" (EarthLab) are also acknowledged. The work is also supported by the program of "Research on Advanced Treatment Technology of Emerging Contaminants in Domestic Sewage of Residential District".

语种：英文

外文关键词：Co-MOF; TiO2; Peroxymonosulfate; Larotrectinib; DFT calculation

摘要：Removal of emerging contaminants has drawn great concern due to their potential high risk to eco-environment system and human health. In this study, an emerging and broad-spectrum anticancer pharmaceutical, larotrectinib (LOXO), was focused on to achieve its degradation in water. A heterogenous peroxymonosulfate (PMS) activation system was constructed by using a comet-like Co-based metal-organic framework (Co-MOF) with TiO2 nanoparticles decorated. The optimized material (TiO2/Co-MOF1) showed high PMS activation efficiency, and thus 90.1 % of LOXO could be quickly degraded within 10 min. Scavenger quenching tests and electron paramagnetic resonance (EPR) analysis indicated that both radicals (center dot OH and SO4 center dot-) and non-radical species (1O2) contributed to LOXO degradation. The two main components of Co-MOF and TiO2 nanoparticles in the composite showed a synergetic effect on PMS activation: Co-MOF offered coordination cobalt for PMS activation, while TiO2 provided abundant -OH groups for interface complexation to promote the electron transfer. In addition, 1O2 originates from directional conversion of center dot O2- after PMS activation at the material's surface. Moreover, density functional theory (DFT) calculation suggests that the atoms in LOXO with high Fukui index (f -) representing electrophilic attack are the reactive sites. Toxicity analysis based on quantitative structure-activity relationship (QSAR) verifies the reduced toxicity of degraded intermediates/products. This work proposed an available technology to efficiently activate PMS for anticancer drugs degradation through both radical and non-radical pathways in wastewater.