文献类型：期刊文献

英文题名：Dual-functional antimicrobial coating based on the combination of zwitterionic and quaternary ammonium cation from rosin acid

作者：Chen, Chaoqi[1] Li, Zhaoshuang[1] Li, Xiangzhou[1] Kuang, Chuntao[1] Liu, Xiubo[1] Song, Zhanqian[2] Liu, He[2] Shan, Yu[3]

第一作者：Chen, Chaoqi

通信作者：Li, ZS[1];Liu, H[2]

机构：[1]Cent South Univ Forestry & Technol, Coll Mat Sci & Engn, Hunan Prov Key Lab Mat Surface Interface Sci & Te, Changsha 410004, Peoples R China;[2]Chinese Acad Forestry, Inst Chem Ind Forestry Prod,Natl Engn Lab Biomass, Key Lab Biomass Energy & Mat,Coinnovat Ctr Effici, Key Lab Chem Engn Forest Prod,Natl Forestry & Gra, Nanjing 210042, Jiangsu, Peoples R China;[3]Jiangsu Prov & Chinese Acad Sci, Inst Bot, Nanjing 210014, Peoples R China

年份：2022

卷号：232

外文期刊名：COMPOSITES PART B-ENGINEERING

收录：;EI(收录号：20220411516086);Scopus(收录号：2-s2.0-85123248779);WOS:【SCI-EXPANDED(收录号:WOS:000748444400003)】；

基金：The authors express their gratitude for financial support from the National Natural Science Foundation of China (31570562) and the Foundation of Jiangsu Province Biomass Energy and Material Laboratory (JSBEM-S-201905).

语种：英文

外文关键词：Antimicrobial; Antibiofilm; Coating; Dopamine; Zwitterionic; Maleopimaric acid quaternary ammonium; cation

摘要：Treatment of implant-associated infection is becoming more challenging, especially when bacterial biofilms form on the surface of implants. To address the challenge of biofilm infection, developing dual-functional antimicrobial coatings (antimicrobial and antifouling) to combat bacterial biofilm infection are superior to those based on a single modality due to avoiding the adverse effects arising from the latter. In this work, we reported an effective dual-functional coating based on the use of synthetic terpolymers, which combined dopamine, zwitterionic 2-methacryloyloxyethyl phosphorylcholine (MPC) and maleopimaric acid quaternary ammonium cation (MPA-N+). The modified surfaces were characterized by scanning electron microscopy-energy dispersive spectroscopy (SEM-EDS), X-ray spectroscopy (XPS) and water contact angle measurements. The bactericidal efficacies of dual-functional coating were demonstrated by 1.00, 1.09 and 0.94 log reduction of Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli, Pseudomonas aeruginosa, respectively, and effectively inhibited pathogenic biofilm formation. Moreover, the dual-function coating reduced protein and platelet absorption, while showing minimal cytotoxicity to the mammalian cells. Notably, an in vivo implantation model showed that the dual-functional coating eradicated the pathogenic biofilm from the implants, preventing host tissue damage and inflammation. Taken together, this dual-functional coating displayed great therapeutic potential in treating the formidable clinic problems caused by pathogenic biofilm and the accompanying inflammation.