文献类型：期刊文献

英文题名：Magnetic Nanoparticle-Based Ligand Replacement Strategy for Chemical Luminescence Determination of Cholesterol

作者：Wu, Yalan[1,2] Peng, Danfeng[1,2] Qi, Zhiwen[3] Zhao, Jing[1,2] Huang, Wenyi[1,2] Zhang, Ying[1,2] Liu, Changhui[4] Deng, Tao[1,2] Liu, Fang[1,2]

第一作者：Wu, Yalan

通信作者：Deng, T[1];Liu, F[1];Deng, T[2];Liu, F[2]

机构：[1]Guangzhou Univ Chinese Med, Inst Trop Med, Guangzhou, Peoples R China;[2]Guangzhou Univ Chinese Med, Artemisinin Res Ctr, Guangzhou, Peoples R China;[3]Chinese Acad Forestry, Inst Chem Ind Forest Prod, Nanjing, Peoples R China;[4]Guangzhou Univ Chinese Med, Sch Pharmaceut Sci, Guangzhou, Peoples R China

年份：2020

卷号：8

外文期刊名：FRONTIERS IN CHEMISTRY

收录：;Scopus(收录号：2-s2.0-85096675181);WOS:【SCI-EXPANDED(收录号:WOS:000591891300001)】；

基金：This work was financially supported by the Youth Scientific Research Training Project of GZUCM (2019QNPY06) and the Hongmian Project from the Science and Technology Bureau of Guangzhou (HMJH-2019-0017).

语种：英文

外文关键词：cholesterol detection; host-guest interaction; chemical luminescence assay; Hemin; smartphone

摘要：Determination of serum cholesterol (Chol) is important for disease diagnosis, and has attracted great attention during the last few decades. Herein, a new magnetic nanoparticle-based ligand replacement strategy has been presented for chemical luminescence detection of Chol. The detection depends on ligand replacement from ferrocene (Fc) to Chol through a beta-cyclodextrin (beta-CD)-based host-guest interaction, which releases Fc-Hemin as a catalyst for the luminol/hydrogen peroxide chemical luminescence system. More importantly, the luminescence signal can be captured by the camera of a smartphone, thus realizing Chol detection with less instrument dependency. The limit of detection of this method is calculated to be 0.18 mu M, which is comparable to some of the developed methods. Moreover, this method has been used successfully to quantify Chol from serum samples with a simple extraction process.