文献类型：期刊文献

英文题名：Trifluoromethoxylation/trifluoromethylthiolation/trifluoro- methylselenolation strategy for the construction of heterocycles

作者：Wang, Xin[1] Wang, Zhichuan[1] Li, Zhenjian[2] Sun, Kai[1]

第一作者：Wang, Xin

通信作者：Sun, K[1]

机构：[1]Yantai Univ, Coll Chem & Chem Engn, Yantai 264005, Peoples R China;[2]Chinese Acad Forestry, Res Inst Forestry, State Key Lab Tree Genet & Breeding, Beijing 100091, Peoples R China

年份：2023

卷号：34

期号：5

外文期刊名：CHINESE CHEMICAL LETTERS

收录：;Scopus(收录号：2-s2.0-85148888835);WOS:【SCI-EXPANDED(收录号:WOS:000947341200001)】；

基金：This work was supported by the National Natural Science Foundation of China (No. 21801007) .

语种：英文

外文关键词：Trifluoromethoxylation; Trifluoromethylthiolation; Trifluoromethylselenolation; Cyclization

摘要：The XCF3 groups (X = O , S, Se) play an increasingly important role in modern organic chemistry due to their unique electronegativity, lipophilic nature, metabolic stability, and bioavailability. Heterocyclic compounds are important scaffolds in many bioactive compounds and drugs. The incorporation of XCF3 groups into heterocyclic compounds can change their physicochemical and biological properties, which injects new vitality into the application of heterocyclic compounds in many fields such as organic chem-istry, the pharmaceutical chemistry, and life sciences. In this paper, the recent progress in the synthesis of F3CX-containing heterocycles is reviewed, and the application scope and mechanism of some reactions are discussed.(c) 2023 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.