文献类型：期刊文献

英文题名：Preparation and evaluation of camptothecin granules for molluscacidal activity

作者：Yang, H. S.[1] Sun, C. X.[1,2] Li, T.[1,3] Li, G. J.[1,4] Ke, W. S.[1,5] Sun, Q. X.[1,6]

第一作者：Yang, H. S.

通信作者：Li, T[1];Sun, QX[1];Li, T[2];Sun, QX[3]

机构：[1]Nanjing Agr Univ, Minist Agr, Key Lab Crop Physiol Ecol & Prod Management, Nanjing 210095, Jiangsu, Peoples R China;[2]Shandong Acad Environm Planning, East Rd 3377, Jinan 250101, Shandong, Peoples R China;[3]Univ Copenhagen, Dept Biol, Terr Ecol Sect, Univ Pk 15, DK-2100 Copenhagen E, Denmark;[4]Chinese Acad Forestry, Inst Desertificat Studies, Beijing, Peoples R China;[5]Hubei Univ, Coll Life Sci, Wuhan 430062, Hubei, Peoples R China;[6]Chinese Acad Forestry, Res Inst Forestry, 1 Dongxiaofu,Xiangshan Rd, Beijing 100091, Peoples R China

年份：2017

卷号：42

期号：1

起止页码：145-155

外文期刊名：ALLELOPATHY JOURNAL

收录：;Scopus(收录号：2-s2.0-85034844079);WOS:【SCI-EXPANDED(收录号:WOS:000412810800012)】；

基金：This work was supported by the National Scientific and Technological Project of China (No. 2015BAD07B07).

语种：英文

外文关键词：Camptotheca acuminata; camptothecin; granules; Oncomelania hupensis; plant; molluscacide; schistosomiasis disease; snail

摘要：To prevent the schistosomiasis disease is to control the intermediate host (snail, Oncomelania hupensis Gredler). We developed and tested an environment-friendly approach to control this snail by preparing the plant molluscacide, camptothecin granules and tested its molluscacidal activity. Aqueous solution (prepared from dissolved granules) of 0.60 g/L concentration of camptothecin showed 100% molluscacidal effect after submerging the O. hupensis for 4-5 days. It reduced the glycogen content, total protein and liver alanine aminotransferase activity in the treated snails. Camptothecin proved safe to fish, at 1.0 g/L for 96 h or 0.40 g/L concentration for 30 days. It prevented the schistosomiasis in schistosomiasis epidemic area in China by controlling the snails growth, that carry the worms causing schistosomiasis.