文献类型：期刊文献

英文题名：Photothermal-Triggered Controlled Drug Release from Mesoporous Silica Nanoparticles Based on Base-Pairing Rules

作者：Li, Xiaoting[1] Wang, Xinhui[1] Hua, Mingli[1] Yu, Haohan[1] Wei, Shaohua[1] Wang, Ao[2] Zhou, Jiahong[1]

第一作者：Li, Xiaoting

通信作者：Zhou, JH[1];Wang, A[2]

机构：[1]Nanjing Normal Univ, Jiangsu Collaborat Innovat Ctr Biomed Funct Mat, Key Lab Appl Photochem, Coll Life Sci,Jiangsu Key Lab Biofunct Mat, Wenyuan Rd, Nanjing 210023, Jiangsu, Peoples R China;[2]Chinese Acad Forestry, Inst Chem Ind Forest Prod, SFA,Key & Open Lab Forest Chem Engn, Natl Engn Lab Biomass Chem Utilizat,Key Lab Bioma, Suojin Fifth Village, Nanjing 210042, Jiangsu, Peoples R China

年份：2019

卷号：5

期号：5

起止页码：2399-2408

外文期刊名：ACS BIOMATERIALS SCIENCE & ENGINEERING

收录：;EI(收录号：20192006915858);Scopus(收录号：2-s2.0-85065490516);WOS:【SCI-EXPANDED(收录号:WOS:000468120000031)】；

基金：This research was financially supported by the National Natural Science Foundation of China (NO. 21671105 and 21571105), the project BK20161554 supported by NSF of Jiangsu Province of China, the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD), the Foundation of Jiangsu Collaborative Innovation Centre of Biomedical Functional Materials (161090H001), and Jiangsu Key Lab of Biomass Energy and Material (JSBEM-S -201804

语种：英文

外文关键词：photothermal controlled drug release; gate keeper; poly adenine; base-pairing rules; antitumor immunity

摘要：Base-pairing is stable under physiological temperature but broken by heating, which is the basic mechanism for nucleic acid amplification in biology. In this manuscript, a simple controlled-drug-release system was prepared on the basis of this rule and its in vivo activity was studied. Poly adenine (poly A), the tail of the synthesized RNA chain, was exploited as gatekeeper of thymine (T) modified mesoporous silica nanoparticles (MSN-T) based on the simple A-T base-pairing rules. The gate keeper maintains stability to avoid drug (chemotherapy and photothermal therapy drugs) release during the delivery process but is effectively removed by a photothermal effect to trigger drug release at the tumor tissue by near-infrared (NIR) laser irradiation. In vitro and in vivo experiments indicated that the prepared nanomedicine could effectively suppress tumor growth and activate antitumor immunity.