文献类型：期刊文献

英文题名：Characterization and anti-Vibrio activity of citral-chitosan Schiff base complexed tannic acid-zinc slow-release bacteriostatic formulations

作者：Wen, Min[1,2] Tao, Ran[3] Jiang, Jianchun[3,4] Chen, Yicun[1,2] Wang, Yangdong[1,2]

第一作者：Wen, Min

通信作者：Chen, YC[1];Wang, YD[1]

机构：[1]Chinese Acad Forestry, State Key Lab Tree Genet & Breeding, Beijing 100091, Peoples R China;[2]Chinese Acad Forestry, Res Inst Subtrop Forestry, Hangzhou 311400, Peoples R China;[3]Chinese Acad Forestry, Inst Chem Ind Forest Prod, Nanjing 210042, Peoples R China;[4]Nanjing Forestry Univ, Nanjing 210037, Peoples R China

年份：2025

卷号：224

外文期刊名：LWT-FOOD SCIENCE AND TECHNOLOGY

收录：;EI(收录号：20251718294256);Scopus(收录号：2-s2.0-105003195273);WOS:【SCI-EXPANDED(收录号:WOS:001481117300001)】；

基金：This project was supported by the National Nonprofit Institute Research Grant of CAFINT (No. AFYBB2022ZA002) and the Ten Thou-sand People Plan of Science and Technology Innovation Leading Talent of Zhejiang, China (No. 2022R52028) awarded to Yicun Chen.

语种：英文

外文关键词：Citral; Chitosan composite; Controlled release; Anti-vibrio agents; Tannic acid-ZnII

摘要：Natural citral has attracted widespread attention for its antibacterial properties, but its instability during processing and in biological systems, such as the gastrointestinal tract, limits its application as an antibiotic alternative. This study aims to enhance the stability and antibacterial efficacy of citral by formulating it into a sustained-release system using Schiff base reaction and metal complexation with chitosan (CS), tannic acid (TA), and zinc (Zn). Characterization of the CS-CT-TA-Schiff base/OH-TA-Zn (CS-CT-TA-Zn) complex revealed a porous, rough morphology with an average particle size of 366.97 +/- 48.02 nm. The composite exhibited a citral loading capacity of 57.78 +/- 1.33 %, with pH-responsive sustained release behavior observed within the pH range of 1.5-2.0. Tannic acid's antioxidant properties helped maintain the formulation's stability. Antimicrobial testing showed that the citral loading in the composite at the Minimum Inhibitory Concentration (MIC) against Vibrio parahaemolyticus was 20 mu g/mL, effectively disrupting the bacterial cell membrane and inhibiting biofilm formation. The CS-CT-TA-Zn complex significantly enhances the stability and antibacterial activity of citral, providing new insights into its application as an antimicrobial agent targeted for delivery to the human stomach, and increasing its potential as a more effective food additive.