文献类型：期刊文献

英文题名：The Research Progress of Taxol in Taxus

作者：Shao, Fenjuan[1] Wilson, Iain W.[2] Qiu, Deyou[1]

第一作者：邵芬娟

通信作者：Qiu, DY[1]|[a000598d4c276c5f9aea6]邱德有;

机构：[1]Chinese Acad Forestry, Res Inst Forestry, State Key Lab Tree Genet & Breeding, Key Lab Tree Breeding & Cultivat,State Forestry A, Beijing, Peoples R China;[2]CSIRO Agr & Food, Canberra, ACT, Australia

年份：2021

卷号：22

期号：3

起止页码：360-366

外文期刊名：CURRENT PHARMACEUTICAL BIOTECHNOLOGY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000623392100003)】；

基金：This work was supported by the Natural Science Foundation of China (grant number 31700584 and 31670676).

语种：英文

外文关键词：Taxus; taxol content; biosynthesis; production; endophytic fungi; multi-omics

摘要：Background: Taxus is a valuable woody species with important medicinal value. The bark of Taxus can produce taxol, a natural antineoplastic drug that is widely used in the treatment of breast, ovarian and lung cancers. However, the low content of taxol in the bark of Taxus can not meet the growing clinical demands, so the current research aims at finding ways to increase taxol production. Objective: In this review, the research progress of taxol including the factors affecting the taxol content, biosynthesis pathway of taxol, production of taxol in vitro and the application of multi-omits approaches in Taxus as well as future research prospects will be discussed. Results: The taxol content is not only dependent on the species, age and tissues but is also affected by light, moisture levels, temperature, soil fertility and microbes. Most of the enzymes in the taxol biosynthesis pathway have been identified and characterized. Total chemical synthesis, semi-synthesis, plant cell culture and biosynthesis in endophytic fungi have been explored to product taxol. Multi-omits have been used to study Taxus and taxol. Conclusion: Further efforts in the identification of unknown enzymes in the taxol biosynthesis pathway, establishment of the genetic transformation system in Taxus and the regulatory mechanism of taxol biosynthesis and Taxus cell growth will play a significant role in improving the yield of taxol in Taxus cells and plants.