文献类型：期刊文献

英文题名：Development of a Cationic Photodynamic Antibacterial Agent Based on Gallic Acid and Ethylene Glycol Diglycidyl Ether and Enriched with Hydroxyl Groups for Effective Antimicrobial Therapy

作者：Zhou, Hao[1,2,3] Qi, Zhiwen[1,2,3] Cheng, Hongxia[1,2,3] Xue, Xingyin[1,2,3] Liu, Lingyan[4] Wang, Chengzhang[1,2,3]

第一作者：周昊;Zhou, Hao

机构：[1] National Key Laboratory for Development and Utilization of Forest Food Resources, Institute of Chemical Industry of Forest Products, Chinese Academy of Forestry, Nanjing, 210042, China; [2] Key Lab. of Biomass Energy and Material, Jiangsu Province, Key Lab. of Chemical Engineering of Forest Products, National Forestry and Grassland Administration, National Engineering Research Center of Low-Carbon Processing, Utilization of Forest Biomass, Nanjing, 210042, China; [3] International Innovation Center for Forest Chemicals and Materials, Jiangsu Co-Innovation Center of Efficient Processing, Utilization of Forest Resources, Nanjing Forestry University, Nanjing, 210037, China; [4] The State Key Laboratory, Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin, 300071, China

年份：2025

外文期刊名：SSRN

收录：EI(收录号：20250240595)

语种：英文

外文关键词：Bactericides - Cell membranes - Escherichia coli - Ethylene - Photodynamic therapy - Photosensitizers - Staphylococcus aureus

摘要：In recent years, various antibiotic-resistant bacterial species have emerged, thereby complicating bacterial infection treatment. Hence, the development of nontraditional, multifunctional, cationic photodynamic antibacterial agents is imperative and valuable to inhibit normal and multidrug-resistant bacterial strains. Here, by performing ring-opening reactions, we successfully synthesized an antibacterial polycation (EY-QEGDM-MG) based on gallic acid, ethylene glycol diglycidyl ether, and eosin Y and enriched with various functional components, namely a photosensitizer, quaternary ammonium (QA), and hydroxyl species. Under light irradiation, the polymer inhibited the growth of both Escherichia coli and methicillin-resistant Staphylococcus aureus because of the combined antibacterial activities of the photosensitizer and the QA group. Evaluation of the mechanism of the antibacterial effect revealed that the polymer binds to the bacterial cell surface and irreversibly damages the cell wall and membrane structure. Furthermore, the polymer also exhibited low cytotoxicity and good hemocompatibility. The antibacterial efficacy of the polymer was assessed in vivo on a rat wound infection model; the polymer showed sustainably enhanced therapeutic effects. Alterations in the levels of CD31-expressing cells and CD68+ macrophages and results of histological analyses validated that the polymer could inhibit bacterial infection in the mice model. The present study provides an efficient approach to develop an effective antimicrobial agent to reduce hospital-acquired bacterial infections. ? 2025, The Authors. All rights reserved.