文献类型：期刊文献

英文题名：Hybrid Fe3O4-poly(acrylic acid) nanogels for theranostic cancer treatment

作者：Chen, Ying[1] Nan, Jingya[1] Lu, Yue[2,3] Wang, Chunpeng[1] Chu, Fuxiang[1] Gu, Zhen[2,3]

第一作者：陈莹

通信作者：Chen, Ying

机构：[1] Institute of Chemical Industry of Forest Products, Chinese Academy of Forestry, Nanjing, 210042, China; [2] Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, North Carolina State University, Raleigh, NC, 27695, United States; [3] Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, United States

年份：2015

卷号：11

期号：5

起止页码：771-779

外文期刊名：Journal of Biomedical Nanotechnology

收录：EI(收录号：20145100345766);Scopus(收录号：2-s2.0-84918575307)

语种：英文

外文关键词：Diagnosis - Diseases - Carboxylic acids - Coprecipitation - Saturation magnetization - Biocompatibility - Targeted drug delivery - Controlled drug delivery - Medical nanotechnology - Magnetite - Nanomagnetics - Nanoparticles - Tumors - Nanostructured materials

摘要：Multifunctional nanomedicine integrated with both therapy and diagnostics holds vast potential in cancer treatment. We developed hybrid Fe3O4-poly(acrylic acid) (PAA) nanogels for both drug delivery and magnetic resonance imaging (MRI). Superparamagnetic Fe3O4 nanoparticles were encapsulated inside porous PAA nanogels via an in situ co-precipitation approach. With successive growth of magnetic nanoparticles, the highest magnetization saturation (Ms) value of the Fe3O4 nanoparticles in the PAA nanogels was determined as 20 emu/g. The resulting hybrid Fe3O4-PAA nanogels showed high drug loading capacity (98%) and sustained drug release in vitro. Cytotoxicity assays and cellular imaging demonstrated that the hybrid nanogels were highly biocompatible and efficiently internalized in human neuroblastoma SH-SY5Y cells. In MRI studies, the hybrid nanogels exhibited an excellent contrast in T2 weighted imaging and a high MRI sensitivity in the tumor site. Copyright ? 2015 American Scientific Publishers.