文献类型：期刊文献

英文题名：Advances in Separation, Biological Properties, and Structure-Activity Relationship of Triterpenoids Derived from Camellia oleifera Abel

作者：Yang, Guliang[1] Qi, Zhiwen[4] Shan, Sijie[1] Xie, Di[2] Tan, Xiaofeng[3]

第一作者：Yang, Guliang

通信作者：Tan, XF[1];Qi, ZW[2]

机构：[1]Cent South Univ Forestry & Technol, Food Sci & Engn Coll, Natl Engn Lab Rice & Byprod Proc, Changsha 410004, Hunan, Peoples R China;[2]Loudi City Farmer Qual Educ Ctr, Loudi 417000, Hunan, Peoples R China;[3]Cent South Univ Forestry & Technol, Acad Camellia Oil Tree, Collaborat Innovat Ctr Cultivat & Utilizat Nonwood, Key Lab Cultivat & Protect Nonwood Forest Trees,Mi, Changsha 410004, Hunan, Peoples R China;[4]Chinese Acad Forestry, Inst Chem Ind Forest Prod, Natl Engn Lab Biomass Chem Utilizat, Nanjing 210042, Jiangsu, Peoples R China

年份：2024

卷号：72

期号：9

起止页码：4574-4586

外文期刊名：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

收录：;EI(收录号：20241015666846);WOS:【SCI-EXPANDED(收录号:WOS:001174388700001)】；

基金：This work was supported by the Hunan Innovative Province Releases Commanding and Unveiling Project (2021JC0007), the Hunan Natural Science Foundation Project (2021JJ31154), and the Scientific Research Projects of Hunan Provincial Department of Education of China (21C0148).

语种：英文

外文关键词：Camellia oleifera Abel; chemical structures; antitumor properties; structure-activity relationship

摘要：Extensive research has been conducted on Camellia oleifera Abel., a cultivar predominantly distributed in China, to investigate its phytochemical composition, owning to its potential as an edible oil crop. Pentacyclic triterpene saponins, as essential active constituents, play a significant role in contributing to the pharmacological effects of this cultivar. The saponins derived from C. oleifera (CoS) offer a diverse array of bioactivity benefits, including antineoplastic/bactericidal/inflammatory properties, cardiovascular protection, neuroprotection, as well as hypoglycemic and hypolipidemic effects. This review presents a comprehensive analysis of the isolation and pharmacological properties of CoS. Specially, we attempt to reveal the antitumor structure-activity relationship (SAR) of CoS-derived triterpenoids. The active substitution sites of CoS, namely, C-3, C-15, C-16, C-21, C-22, C-23, and C-28 pentacyclic triterpenoids, make it a unique and highly valuable substance with significant medicinal and culinary applications. As such, CoS can play a critical role in transforming people's lives, providing unique medicinal benefits, and contributing to the advancement of both medicine and cuisine.