文献类型：期刊文献

英文题名：Preparation of Targeted Lignin-Based Hollow Nanoparticles for the Delivery of Doxorubicin

作者：Zhou, Yu[1] Han, Yanming[1] Li, Gaiyun[1] Yang, Sheng[1] Xiong, Fuquan[2] Chu, Fuxiang[1]

第一作者：周宇

通信作者：Han, YM[1];Chu, FX[1]|[a0005728d87cb2daf502d]储富祥;

机构：[1]Chinese Acad Forestry, Res Inst Wood Ind, Xiangshan Rd, Beijing 100089, Peoples R China;[2]Cent South Univ Forestry & Technol, Coll Mat Sci & Engn, Changsha 410004, Hunan, Peoples R China

年份：2019

卷号：9

期号：2

外文期刊名：NANOMATERIALS

收录：;Scopus(收录号：2-s2.0-85062655860);WOS:【SCI-EXPANDED(收录号:WOS:000460806700057)】；

基金：This study was financially support by National Natural Science Foundation of China (31770610) and NationalNon-profit Special Fund for Fundamental Research from Chinese Academy of Forestry (CAFYBB2017ZX003).

语种：英文

外文关键词：lignin; nanoparticles; targeted materials; drug delivery

摘要：Due to their exceptional absorption capacity, biodegradability, and non-toxicity, nanoparticles (NPs) from lignin have emerged as vehicles for inorganic particles and drug molecules. However, the method for preparing targeted lignin particles is still complex and lacks sufficient research. Herein, a succinct strategy was proposed for the preparation of targeted lignin-based drug delivery NPs to load Doxorubicin Hydrochloride (DOX). The lignin hollow NPs (LHNPs) were used as a platform for the preparation of targeted delivery material by incorporating magnetic NPs and folic acid (FA) via layer-by-layer self-assembling. The results showed that the surface of LHNPs was covered uniformly by Fe3O4 NPs and grafted with folic acid. The folic-magnetic-functionalized lignin hollow NPs (FA-MLHNPs) could respond to magnetic field and folic acid receptors. In addition, the targeting performance of the FA-MLHNPs increased the cellular uptake of NPs in the case of HeLa cells. This research not only supported the modified NPs platform as a highly efficient nano-delivery method but also provided a facile approach to utilize renewable lignin biomaterials.