文献类型：期刊文献

中文题名：复合植物性鼠类不育剂的毒理学研究

英文题名：Toxicology of botanical compound rodent sterilant

作者：石淳[1] 唐桦[2] 石滨[3] 史琴[3] 李红兵[3] 蔺成阁[4]

第一作者：石淳

机构：[1]北方民族大学生物科学与工程学院;[2]中国林业科学研究院森林生态环境与保护研究所/国家林业局森林保护学重点实验室;[3]宁夏医科大学;[4]吉林省黄泥河林业局

年份：2014

卷号：33

期号：1

起止页码：1-4

中文期刊名：中国森林病虫

外文期刊名：Forest Pest and Disease

收录：CSTPCD;;北大核心:【北大核心2011】；

基金：宁夏自然科学基金项目(NZ11140)

语种：中文

中文关键词：不育剂;鼠;生化指标;急性毒性;长期毒性

外文关键词：sterilant; rat; biochemical indicators; acute toxicity; chronic toxicity

分类号：S481.1

摘要：为搞清复合植物性鼠类不育剂对人畜的安全性,采用向SD大鼠经口灌胃不同剂量不育剂的方法,进行了急性毒性和长期毒性研究。结果表明:该鼠类不育剂属低毒(LD50为4640.3±127.1mg/kg),无明显致死作用,可列为毒性极低物质,可在控制鼠害中安全应用并大面积推广;但在高剂量下,对雌雄大鼠心脏功能、雄鼠肝功能和雄鼠血液相关指标中的极少数生化指标造成偏高或偏低的影响,应注意使用剂量不能过大,避免对生态环境造成不利影响。
In order to know the safety of botanical compound rodent sterilant to human being, the acute and chronic toxicity were studied by injecting different doses of sterilant through the mouth to stomachs of SD rats. The results showed that the acute toxicity of this sterilant was low with an LDso of 4640. 3 ± 127. 1 mg/kg and had no obvious lethal effect, which could be classified as an extremely low toxic sub-stances; but in high doses, a few biochemical indicators of heart function of male and female rats, liver function and blood related indicators of male rats were relative high or low. So this sterilant can be a- dopted to control rats safely and popularized in large area, but the high dose should be avoid for its ad- verse effects on the ecological environment.