文献类型：期刊文献

英文题名：Construction of a Carboxymethyl cellulose-Based Intelligent Response Matrine Nanogel Pesticide and its Efficient Delivery and Application

作者：Zhang, Jiakang[1] Xu, Jiahui[1] Peng, Chen[1] Mo, Chenlong[1] Lin, Hanchen[1] Wang, Fei[1] You, Chaoqun[1] Zhang, Daihui[2]

第一作者：Zhang, Jiakang

机构：[1] Jiangsu Co-Innovation Centre of Efficient Processing and Utilization of Forest Resources, Jiangsu Key Lab for the Chemistry and Utilization of Agro-Forest Biomass, College of Chemical Engineering, Nanjing Forestry University, Nanjing, 210037, China; [2] Institute of Chemical Industry of Forest Products, Chinese Academy of Forestry, Nanjing, 210042, China

年份：2025

外文期刊名：SSRN

收录：EI(收录号：20250535469)

语种：英文

外文关键词：Biocompatibility - Cellulose - Controlled drug delivery - Drug products - Erosion - Nanogels - Pesticides - Plants (botany) - Sustainable development - Targeted drug delivery - Toxicity - Wetting

摘要：Constructing an intelligent pesticide delivery system based on nanomaterials, which can dynamically modulate drug release through environmental response mechanisms, while simultaneously enhancing pesticide adhesion on leaf surfaces and their resistance to rainwater erosion, is a key strategy for improving targeted pesticide utilization and reducing environmental residue risks. 8In this study, an environmentally responsive controlled-release pesticide system was developed using carboxymethyl cellulose (CMC) as the carrier framework. By incorporating tea saponin (TS), tannic acid (TA), and polyethyleneimine (PEI) to form a biocompatible interpenetrating network gel (CPTT), and further loading matrine (MT) to construct a stable three-dimensional mesh structure (MT@CPTT@SLS), the resulting nano-gel demonstrates pH-sensitive drug release behavior. Compared with free MT, this system significantly enhances leaf wetting capability, resistance to rainwater erosion, and controlled-release performance. Moreover, insecticidal toxicity tests indicate that its efficacy against diamondback moth larvae is higher than that of free MT at the same concentration. Additionally, zebrafish acute toxicity experiments confirm its acceptable level of aquatic biotoxicity safety. This research provides a promising strategy for the application of intelligent nano-pesticides in green plant protection by integrating efficient targeted delivery with environmentally sustainable properties. ? 2025, The Authors. All rights reserved.