文献类型：期刊文献

英文题名：Facile preparation of a novel nanoemulsion based hyaluronic acid hydrogel loading with Poria cocos triterpenoids extract for wound dressing

作者：Ding, Xiaofeng[1] Li, Shiyan[2] Tian, Meng[3] Yang, Ping[2] Ding, Youjun[4] Wang, Yiwei[5,6] Duan, Guomei[10] Zhang, Daihui[7] Chen, Bin[9] Tan, Qian[1,2,8]

第一作者：Ding, Xiaofeng

通信作者：Tan, Q[1];Zhang, DH[2];Chen, B[3]

机构：[1]Nanjing Univ Chinese Med, Nanjing Drum Tower Hosp Clin Coll Tradit Chinese &, Nanjing 210008, Peoples R China;[2]Nanjing Univ, Nanjing Drum Tower Hosp, Affiliated Hosp,Med Sch, Dept Burns & Plast Surg, 321 Zhongshan Rd, Nanjing, Jiangsu, Peoples R China;[3]Tongji Univ, Shanghai Peoples Hosp 4, Sch Med, Dept Plast Surg, Shanghai 200434, Peoples R China;[4]Jiangsu Univ, Nanjing Drum Tower Hosp Clin Coll, Dept Burns & Plast Surg, Nanjing, Jiangsu, Peoples R China;[5]Nanjing Univ Chinese Med, Jiangsu Prov Engn Res Ctr TCM External Medicat Dev, Nanjing, Peoples R China;[6]Univ Sydney, Concord Hosp, ANZAC Res Inst, Burns & Reconstruct Surg Res Grp, Sydney, Australia;[7]Chinese Acad Forestry, Inst Chem Ind Forest Prod, Nanjing 210042, Jiangsu, Peoples R China;[8]Anqing Shihua Hosp Nanjing Drum Tower Hosp Grp, Dept Burns & Plast Surg, Anqing, Anhui, Peoples R China;[9]Inst Plant Resources & Chem, Nanjing Res Inst Comprehens Utilizat Wild Plants, Nanjing 210042, Peoples R China;[10]Guangzhou Q Land Innovat Technol Co Ltd, Guangzhou 510800, Peoples R China

年份：2023

卷号：226

起止页码：1490-1499

外文期刊名：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

收录：;Scopus(收录号：2-s2.0-85145275086);WOS:【SCI-EXPANDED(收录号:WOS:000994889700001)】；

基金：Acknowledgements We acknowledge the support from The National Natural Science Foundation of China (No. 81974288 and 81671922) .

语种：英文

外文关键词：Poria cocos; Nanoemulsions; Hyaluronic acid; Hydrogels; Diabetic wound

摘要：Diabetic wounds have been a serious concern for human health owing to their long chronic inflammation and reduced vascularization. Herein, we report novel oil-in-water (o/w) nanoemulsions (NEs) containing Poria cocos triterpenes extract (PTE) to fabricate hyaluronic acid hydrogels (PTE-NEs) for the treatment of diabetic wounds. The size and morphology of NEs are analyzed by transmission electron microscope (TEM) and Zeta potential, respectively. Furthermore, the rheological behavior and morphology of synthesized hydrogels are also deter-mined. It is found that PTE-NEs gel has a homogeneous and porous structure with good elastic properties. In addition, in vitro experiments show that the cell viability of PTE-NEs gel is >85 % without cytotoxicity. In vivo experiments of diabetic rats demonstrate that the PTE-NEs gel can not only significantly accelerate diabetic wound healing, collagen deposition, M2 macrophage polarization, and angiogenesis, but also inhibit inflam-mation. In conclusion, PTE plays a significant role in wound healing and exhibits anti-inflammatory effects, demonstrating its great potential in treating diabetic wounds.