文献类型：期刊文献

中文题名：马尾松针叶聚戊烯醇对阿尔茨海默病模型小鼠学习记忆的影响

英文题名：Effect of polyprenols from pine needles of Pinus massoniana on ability of learning and memory in a mouse model of Alzheimer's disease

作者：郑光耀[1] 何玲[2] 薄采颖[1] 王萌萌[2] 余涛[2] 周维纯[1]

第一作者：郑光耀

机构：[1]中国林业科学研究院林产化学工业研究所生物质化学利用国家工程实验室国家林业局林产化学工程重点开放性实验室;[2]中国药科大学药理教研室

年份：2011

卷号：20

期号：20

起止页码：2014-2017

中文期刊名：中国新药杂志

外文期刊名：Chinese Journal of New Drugs

收录：CSTPCD;;Scopus;北大核心:【北大核心2008】；CSCD:【CSCD_E2011_2012】；

基金：中央高校基本科研业务费专项资金项目(JKZ2009005);科技部农业科技成果转化资金项目(2008GB24320412);教育部"新世纪优秀人才"支持计划(NCET-10-0817)

语种：中文

中文关键词：提取物;聚戊烯醇;阿尔茨海默病;动物模型;β-淀粉样蛋白

外文关键词：extract; polyprenol; Alzheimer＇s disease; animal model; amyloid beta-protein

分类号：R971

摘要：目的:观察马尾松针叶聚戊烯醇对阿尔茨海默病(AD)模型小鼠学习记忆能力的影响。方法:将140只小鼠随机分为正常对照组、假手术组、AD模型组、石杉碱甲组(0.3 mg.kg-1)、聚戊烯醇低、中、高剂量组(20,408,0 mg.kg-1),灌胃给药14 d后,一次性右侧侧脑室注射聚集态β-淀粉样蛋白(Aβ1～42)5μg制备AD小鼠模型,继续给药7 d后,通过避暗实验和Morris水迷宫实验测定AD小鼠学习记忆能力。结果:马尾松针叶聚戊烯醇408,0 mg.kg-1剂量组能明显提高AD小鼠被动回避记忆能力和空间学习记忆能力(P<0.05或0.01),且高剂量针叶聚戊烯醇(80 mg.kg-1)与0.3 mg.kg-1石杉碱甲的效果相似。结论:马尾松针叶聚戊烯醇能明显改善AD小鼠学习记忆的能力,提示马尾松针叶聚戊烯醇对AD小鼠具有一定的防治作用。
Objective： To determine the effect of polyprenols from pine needles of P.Massoniana on the ability of learning and memory in a mouse model of Alzheimer＇s disease（AD）.Methods： A total of 140 mice were randomly divided into groups,oral polyprenols at 20,40 and 80mg·kg-1 were administered for 14 days,and huperzine A was used as control.AD model was induced by a single intraventricular injection of aggregated Aβ1~42（5μg）,and then the agents were continuously given for other 7 days.Step-through test and Morris water maze were used to investigate the ability of learning and memory.Results： The polyprenols at 40 and 80mg·kg-1 significantly improved the passive avoidance memory and spatial learning memory in AD mice.The effect of 80mg·kg-1 polyprenols was similar to that of 0.3mg·kg-1 huperzine A.Conclusion： The polyprenols from pine needles can significantly improve the ability of learning and memory of AD mice,suggesting a therapeutic potential for AD.