文献类型：期刊文献

英文题名：Achievements and Perspectives in 1,4-Butanediol Production from Engineered Microorganisms

作者：Cheng, Jie[1] Li, Juan[1,2] Zheng, Linggang[1,3]

第一作者：Cheng, Jie

通信作者：Cheng, J[1]

机构：[1]Xiamen Univ, Coll Ocean & Earth Sci, State Key Lab Marine Environm Sci, Xiamen 361102, Fujian, Peoples R China;[2]Chinese Acad Forestry, Res Inst Trop Forestry, Key Lab State Forestry & Grassland Adm Trop Fores, Guangzhou 510520, Guangdong, Peoples R China;[3]Macau Univ Sci & Technol, Dr Nehers Biophys Lab Innovat Drug Discovery, State Key Lab Qual Res Chinese Med, Taipa 999078, Macao, Peoples R China

年份：2021

卷号：69

期号：36

起止页码：10480-10485

外文期刊名：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

收录：;EI(收录号：20213810909127);Scopus(收录号：2-s2.0-85115011951);WOS:【SCI-EXPANDED(收录号:WOS:000697283600006)】；

语种：英文

外文关键词：1,4-butanediol; biosynthesis; biocatalysis; metabolic engineering; Escherichia coli

摘要：1,4-Butanediol (1,4-BDO), a significant commodity chemical, is currently manufactured exclusively from a host of energy-intensive processes, accompanied by severe environmental issues, such as the greenhouse effect and air pollution. As a result of the ever-increasing global market demands and increasing applications of 1,4-BDO, attention has turned to the sustainable bioproduction of 1,4-BDO, and several bio-based approaches for 1,4-BDO production have been successfully established in engineered Escherichia coli, including de novo biosynthesis and biocatalysis. Recent achievements in enhancing the accumulation of 1,4-BDO have been achieved by metabolic engineering strategies, such as improving precursor supply, enhancing activities of critical enzymes, and fewer byproduct synthesis. Here, we summarize the primary advances of the biological pathway for 1,4-BDO synthesis and put forward the future development prospect of bio-based 1,4-BDO production.