文献类型：期刊文献

英文题名：Polymeric Hydrogel Nanocapsules: A Thermo and pH Dual-responsive Carrier for Sustained Drug Release

作者：Nan, Jingya[1] Chen, Ying[1,2] Li, Rutian[3,4] Wang, Jifu[1] Liu, Meihong[1] Wang, Chunpeng[1] Chu, Fuxiang[5]

第一作者：Nan, Jingya

通信作者：Chen, Y[1]|[a0005125116bcee0aa95c]陈莹;

机构：[1]Chinese Acad Forestry, Key Lab Biomass Energy & Mat Jiangsu Prov, Key & Open Lab Forest Chem Engn, Inst Chem Ind Forest Prod,Natl Engn Lab Biomass C, Nanjing 210042, Jiangsu, Peoples R China;[2]Chinese Acad Forestry, Inst New Technol, Beijing 100091, Peoples R China;[3]Nanjing Univ, Ctr Comprehens Canc, Drum Tower Hosp, Nanjing 210008, Jiangsu, Peoples R China;[4]Nanjing Univ, Clin Canc Inst, Nanjing 210008, Jiangsu, Peoples R China;[5]Chinese Acad Forestry, Beijing 100091, Peoples R China

年份：2014

卷号：6

期号：3

起止页码：200-208

外文期刊名：NANO-MICRO LETTERS

收录：;EI(收录号：20175204579860);Scopus(收录号：2-s2.0-84958741832);WOS:【SCI-EXPANDED(收录号:WOS:000339891700002)】；

基金：This work is financially supported by the National Natural Science Foundation of China (Grant No. 31100427, No. 81101751) and the Jiangsu Province Natural Science Foundation (BK20131071).

语种：英文

外文关键词：Hydrogel capsules; Sustained release; High drug loading; Dual responsivity

摘要：Hydrogel capsules show attractive prospects in drug delivery recently because of high drug loading and sustained release behavior. In this study we reported a simple and convenient route to fabricate poly (acrylic acid)-poly (N-isopropylacrylamide) (PAA-PNIPAm) hydrogel capsules by using hydroxypropylcellulose-poly (acrylic acid) (HPC-PAA) complexes as the templates. The capsules showed a high drug loading (similar to 280% to the weight of capsules) for Doxorubicin hydrochloride. The release of drug from the capsules was responsive to the temperature and pH of the surroundings, showing a low-rate but sustained release behavior favorable for low-toxic and long-term therapy. Together with the convenient preparation, high drug loading, dual responsivity as well as the sustained release feature, it is implied that this polymeric hydrogel capsule might be a promising candidate for new drug carriers.