文献类型：期刊文献

英文题名：Synthesis and anticancer activity of (+)-nopinone-based 2-amino-3-cyanopyridines

作者：Liao, Shengliang[1,2,3,4] Shang, Shibin[1,2,3,4] Shen, Minggui[1,2,3,4] Rao, Xiaoping[1,2,3,4] Si, Hongyan[1,2,3,4] Song, Jie[5] Song, Zhanqian[1,2,3,4]

第一作者：Liao, Shengliang

通信作者：Song, ZQ[1]

机构：[1]China Acad Forestry, Inst Chem Ind Forest Prod, Nanjing 210042, Jiangsu, Peoples R China;[2]Natl Engn Lab Biomass Chem Utilizat, Nanjing 210042, Jiangsu, Peoples R China;[3]State Forestry Adm Key & Open Lab Forest Chem Eng, Nanjing 210042, Jiangsu, Peoples R China;[4]Jiangsu Prov Key Lab Biomass Energy & Mat, Nanjing 210042, Jiangsu, Peoples R China;[5]Univ Michigan Flint, Dept Chem & Biochem, Flint, MI 48502 USA

年份：2015

卷号：2

期号：4

起止页码：335-340

外文期刊名：FRONTIERS OF AGRICULTURAL SCIENCE AND ENGINEERING

收录：Scopus(收录号：2-s2.0-85034846973);WOS:【ESCI(收录号:WOS:000409683900007)】；

基金：This work was supported by the Joint Funds of the National Natural Science Foundation of China and Yunnan Provincial Government (U1202265).

语种：英文

外文关键词：beta-pinene; nopinone; synthesis; 2-amino-3cyanopyridine; anticancer

摘要：Twelve (+)-nopinone-based 2-amino-3-cyanopyridines 4a-l were synthesized from (-)-beta-pinene. The structures of these compounds were characterized by FT-IR, 1H NMR, and ESI-MS. All the compounds were tested for their anticancer activity against lung cancer cell line A549, gastric cancer cell line MKN45 and breast cancer cell line MCF7 by MTT method, respectively. The results showed that compounds 4f, 4j and 4k had promising anticancer activity against these cancer cell lines, in particular, compound 4f exhibited broad-spectrum and highly efficient anticancer activity against cell lines A549, MKN45 and MCF7 with IC50 of 23.78, 67.61 and 53.87 mu mol center dot L-1, respectively. The preliminary analysis of the structure activity relationship implied that the Br or Cl substituted group of the benzene ring in these derivatives significantly contributed to the anticancer activity.